Differential roles of leptin in regulating cell migration in thyroid cancer cells

被引：43

作者：

Cheng, Shih-Ping ^{[3
,4
]}

Yin, Pen-Hui ^{[1
]}

Chang, Yuan-Ching ^{[4
]}

Lee, Chen-Hsen ^{[1
,2
,5
]}

Huang, Shih-Yuan ^{[4
]}

Chi, Chin-Wen ^{[1
,3
]}

机构：

[1] Taipei Vet Gen Hosp, Dept Med Res & Educ, Taipei 11217, Taiwan

[2] Taipei Vet Gen Hosp, Dept Surg, Taipei 11217, Taiwan

[3] Natl Yang Ming Univ, Sch Med, Dept & Inst Pharmacol, Taipei 112, Taiwan

[4] Mackay Mem Hosp, Dept Surg, Taipei, Taiwan

[5] Natl Yang Ming Univ, Sch Med, Dept Surg, Taipei 112, Taiwan

来源：

ONCOLOGY REPORTS | 2010年 / 23卷 / 06期

关键词：

leptin; leptin receptor; thyroid cancer; migration; adipokines; BREAST-CANCER; HEPATOCELLULAR-CARCINOMA; MESSENGER-RNA; IODIDE UPTAKE; CYCLIN D1; IN-VITRO; EXPRESSION; RECEPTOR; INVASION; MECHANISMS;

D O I：

10.3892/or_00000817

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Excess body weight is associated with a moderately increased risk of thyroid cancer. Adipocyte-derived hormone, leptin, has been shown to enhance cell growth and migration in many cancer types. Limited evidence suggests that leptin has direct actions on the thyroid gland, but there are no data available on the effect of leptin on thyroid cancer cells. We evaluated the action of leptin on gene expression, cell growth, cell cycle, and cell migration in anaplastic (ARO), follicular (WRO) and papillary (CGTH-W3) thyroid carcinoma cell lines. Expression of long-form leptin receptors was observed in all thyroid cancer cell lines. Leptin stimulation did not alter the expression levels of leptin, leptin receptor and sodium-iodide symporter. Cell growth and cell cycle were not changed after leptin treatment. However, leptin was able to promote cell migration of papillary thyroid cancer cells, but inhibited migration of anaplastic and follicular cancer cells. In summary, our study suggests that leptin modulates cell migration of thyroid cancer cells in a cell type-specific manner.

引用

页码：1721 / 1727

页数：7

共 30 条

[1]

Obesity and cancer [J].

Calle, EE ;

Thun, MJ .

ONCOGENE, 2004, 23 (38) :6365-6378

[2]

Leptin induces proliferation and anti-apoptosis in human hepatocarcinoma cells by up-regulating cyclin D1 and down-regulating Bax via a Janus kinase 2-linked pathway [J].

Chen, Chiachen ;

Chang, Yuan-Ching ;

Liu, Chien-Liang ;

Liu, Tsang-Pai ;

Chang, King-Jen ;

Guo, Ing-Cherng .

[3]

Leptin-induced growth of human ZR-75-1 breast cancer cells is associated with up-regulation of cyclin D1 and c-Myc and down-regulation of tumor suppressor p53 and p21WAF1/CIP1 [J].

Chen, Chiachen ;

Chang, Yuan-Ching ;

Liu, Chien-Liang ;

Chang, King-Jen ;

Guo, Ing-Cherng .

BREAST CANCER RESEARCH AND TREATMENT, 2006, 98 (02) :121-132

[4]

Characteristics of well-differentiated thyroid cancer associated with multinodular goiter [J].

Cheng, Shih-Ping ;

Liu, Chien-Liang ;

Tzen, Chi-Yuan ;

Yang, Tsen-Long ;

Jeng, Kuo-Shyang ;

Liu, Tsang-Pai ;

Lee, Jie-Jen .

LANGENBECKS ARCHIVES OF SURGERY, 2008, 393 (05) :729-732

[5]

Risk factors for thyroid cancer: an epidemiological review focused on nutritional factors [J].

Dal Maso, Luigino ;

Bosetti, Cristina ;

La Vecchia, Carlo ;

Franceschi, Silvia .

CANCER CAUSES & CONTROL, 2009, 20 (01) :75-86

[6]

Increasing incidence of thyroid cancer in the United States, 1973-2002 [J].

Davies, L ;

Welch, HG .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 295 (18) :2164-2167

[7]

Acute and chronic leptin effect upon in vivo and in vitro rat thyroid iodide uptake [J].

De Oliveira, Elaine ;

Fagundes, Aline Teixeira Silva ;

Bonomo, Isabela Teixeira ;

Flavio, Henrique Curty ;

Passos, Magna Cottini Fonseca ;

de Moura, Egberto Gaspar ;

Lisboa, Patricia Cristina .

LIFE SCIENCES, 2007, 81 (15) :1241-1246

[8]

Body size and thyroid cancer in two million Norwegian men and women [J].

Engeland, A. ;

Tretli, S. ;

Akslen, L. A. ;

Bjorge, T. .

BRITISH JOURNAL OF CANCER, 2006, 95 (03) :366-370

[9]

Polarity proteins in migration and invasion [J].

Etienne-Manneville, S. .

ONCOGENE, 2008, 27 (55) :6970-6980

[10]

Thyroid and leptin [J].

Feldt-Rasmussen, Ulla .

THYROID, 2007, 17 (05) :413-419

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