Insulin secretion capacity in the development from normal glucose tolerance to type 2 diabetes

被引:251
作者
Fukushima, M [1 ]
Suzuki, H [1 ]
Seino, Y [1 ]
机构
[1] Kyoto Univ, Grad Sch Med, Dept Diabet & Clin Nutr, Sakyo Ku, Kyoto 6068507, Japan
关键词
insulin secretion; insulin sensitivity; insulinogenic index; HOMA-IR; ISI composite;
D O I
10.1016/j.diabres.2003.11.024
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We have examined the contribution of insulin secretion and insulin resistance to glucose intolerance in Japanese. Some indices of insulin secretion and insulin sensitivity based on the results of OGTT were used. The decline of insulin secretion capacity was significant throughout the development of glucose intolerance from NGT via IGT to DM. Decreased insulinogenic indices were conspicuous when it is compared with other types of diabetes. Slight impairment of insulin secretion has begun in subjects with NGT. The progression from NGT via isolated IGT to isolated post-challenge hyperglycemia was considered mostly due to the deterioration of early-phase insulin secretion. It is summazied that decreased insulin secretion capacity takes a definite role in the development from NGT to type 2 diabetes in Japan. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:S37 / S43
页数:7
相关论文
共 38 条
  • [31] INSULINOGENIC INDEX IN SECONDARY DIABETES
    SEINO, Y
    IKEDA, M
    YAWATA, M
    IMURA, H
    [J]. HORMONE AND METABOLIC RESEARCH, 1975, 7 (02) : 107 - 115
  • [32] PREVALENCE OF DIABETES AND IMPAIRED GLUCOSE-TOLERANCE IN FUNAGATA AREA, JAPAN
    SEKIKAWA, A
    TOMINAGA, M
    TAKAHASHI, K
    EGUCHI, H
    IGARASHI, M
    OHNUMA, H
    SUGIYAMA, K
    MANAKA, H
    SASAKI, H
    FUKUYAMA, H
    MIYAZAWA, K
    [J]. DIABETES CARE, 1993, 16 (04) : 570 - 574
  • [33] INSULIN SECRETION IN RESPONSE TO GLYCEMIC STIMULUS - RELATION OF DELAYED INITIAL RELEASE TO CARBOHYDRATE INTOLERANCE IN MILD DIABETES MELLITUS
    SELTZER, HS
    ALLEN, EW
    HERRON, AL
    BRENNAN, MT
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1967, 46 (03) : 323 - &
  • [34] Factors responsible for development from normal glucose tolerance to isolated postchallenge hyperglycemia
    Suzuki, H
    Fukushima, M
    Usami, M
    Ikeda, M
    Taniguchi, A
    Nakai, Y
    Matsuura, T
    Kuroe, A
    Yasuda, K
    Kurose, T
    Seino, Y
    Yamada, Y
    [J]. DIABETES CARE, 2003, 26 (04) : 1211 - 1215
  • [35] TANIGUCHI A, 2001, METABOLISM, P50
  • [36] Insulin secretion and insulin sensitivity in relation to glucose tolerance - Lessons from the Botnia Study
    Tripathy, D
    Carlsson, M
    Almgren, P
    Isomaa, B
    Taskinen, MR
    Tuomi, T
    Groop, LC
    [J]. DIABETES, 2000, 49 (06) : 975 - 980
  • [37] Insulin secretion and insulin sensitivity in diabetic subgroups:: studies in the prediabetic and diabetic state
    Tripathy, D
    Carlsson, ÅL
    Lehto, M
    Isomaa, B
    Tuomi, T
    Groop, L
    [J]. DIABETOLOGIA, 2000, 43 (12) : 1476 - 1483
  • [38] Relationship between several surrogate estimates of insulin resistance and quantification of insulin-mediated glucose disposal in 490 healthy nondiabetic volunteers
    Yeni-Komshian, H
    Carantoni, M
    Abbasi, F
    Reaven, GM
    [J]. DIABETES CARE, 2000, 23 (02) : 171 - 175