Chemical Nanosensors Based on Composite Molecularly Imprinted Polymer Particles and Surface-Enhanced Raman Scattering

被引:87
作者
Bompart, Marc [2 ]
De Wilde, Yannick [1 ]
Haupt, Karsten [2 ]
机构
[1] ESPCI ParisTech, Inst Langevin, Lab Opt Phys, CNRS,UMR 7587, F-75231 Paris 05, France
[2] Univ Technol Compiegne, CNRS, UMR 6022, F-60205 Compiegne, France
关键词
GOLD NANOPARTICLES; SILVER ELECTRODE; SPECTROSCOPY; PYRIDINE; SITES; SERS;
D O I
10.1002/adma.200904442
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Chemical nanosensors with a submicrometer core-shell composite design, based on a polymer core, a molecularly imprinted polymer (MIP) shell for specific analyte recognition, and an interlayer of gold nanoparticles for signal amplification, are described. SERS measurements on single nanosensors yield detection limits of 10(-7) M for the beta-blocker propranolol, several orders of magnitude lower than on plain MIP spheres.
引用
收藏
页码:2343 / 2348
页数:6
相关论文
共 28 条
[1]   ANOMALOUSLY INTENSE RAMAN-SPECTRA OF PYRIDINE AT A SILVER ELECTRODE [J].
ALBRECHT, MG ;
CREIGHTON, JA .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1977, 99 (15) :5215-5217
[2]   Application of molecular imprinting to the development of aqueous buffer and organic solvent based radioligand binding assays for (S)-propranolol [J].
Andersson, LI .
ANALYTICAL CHEMISTRY, 1996, 68 (01) :111-117
[3]  
ARSHADY R, 1981, MACROMOL CHEM PHYS, V182, P687
[4]   Direct detection of analyte binding to single molecularly imprinted polymer particles by confocal Raman spectroscopy [J].
Bompart, Marc ;
Gheber, Levi A. ;
De Wilde, Yannick ;
Haupt, Karsten .
BIOSENSORS & BIOELECTRONICS, 2009, 25 (03) :568-571
[5]   NORMAL RAMAN-SCATTERING FROM PYRIDINE ADSORBED ON THE LOW-INDEX FACES OF SILVER [J].
CAMPION, A ;
MULLINS, DR .
CHEMICAL PHYSICS LETTERS, 1983, 94 (06) :576-579
[6]   Surface-enhanced Raman scattering [J].
Campion, A ;
Kambhampati, P .
CHEMICAL SOCIETY REVIEWS, 1998, 27 (04) :241-250
[7]  
Hughes L.J., 1961, Journal of Applied Polymer Science, V5, P580
[8]   Molecularly imprinted polymers and infrared evanescent wave spectroscopy. A chemical sensors approach [J].
Jakusch, M ;
Janotta, M ;
Mizaikoff, B ;
Mosbach, K ;
Haupt, K .
ANALYTICAL CHEMISTRY, 1999, 71 (20) :4786-4791
[9]   SURFACE RAMAN SPECTROELECTROCHEMISTRY .1. HETEROCYCLIC, AROMATIC, AND ALIPHATIC-AMINES ADSORBED ON ANODIZED SILVER ELECTRODE [J].
JEANMAIRE, DL ;
VANDUYNE, RP .
JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 1977, 84 (01) :1-20
[10]   ELECTROCHEMICAL AND RAMAN CHARACTERIZATION OF MOLECULAR RECOGNITION SITES IN SELF-ASSEMBLED MONOLAYERS [J].
KIM, JH ;
COTTON, TM ;
UPHAUS, RA .
JOURNAL OF PHYSICAL CHEMISTRY, 1988, 92 (20) :5575-5578