One-pot synthesis of chiral N-protected-4-amino functionalized but-2-enoates from α-amino acids mediated by 1-hydroxybenzotriazole

被引：4

作者：

Athanasellis, G ^{[1
]}

Gavrielatos, E ^{[1
]}

Igglessi-Markopoulou, O ^{[1
]}

机构：

[1] Natl Tech Univ Athens, Dept Chem Engn, Organ Chem Lab, Athens 15773, Greece

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 2002年 / 75卷 / 12期

关键词：

D O I：

10.1246/bcsj.75.2691

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel one-pot synthetic route to 4-acetylamino-2-cyano-3-hydroxybut-2-enoates in good yields (63-71%) is reported. An HPLC analysis of these compounds showed very good enantiomeric excesses (90-94%), justifying the success of our methodology to maintain the stereochemical integrity of the starting materials used.

引用

页码：2691 / 2692

页数：2

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