Going both ways: immune regulation via CD1d-dependent NKT cells

被引：684

作者：

Godfrey, DI ^{[1
]}

Kronenberg, M

机构：

[1] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia

[2] La Jolla Inst Allergy & Immunol, San Diego, CA USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 114卷 / 10期

关键词：

D O I：

10.1172/JCI200423594

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

NKT cells are a unique T lymphocyte sublineage that has been implicated in the regulation of immune responses associated with a broad range of diseases, including autoimmunity, infectious diseases, and cancer. in stark contrast to both conventional T lymphocytes and other types of Tregs, NKT cells are reactive to the nonclassical class I antigen-presenting molecule CD1d, and they recognize glycolipid antigens rather than peptides. Moreover, they can either up- or downregulate immune responses by promoting the secretion of Th1, Th2, or immune regulatory cytokines. This review will explore the diverse influences of these cells in various disease models, their ability to suppress or enhance immunity, and the potential for manipulating these cells as a novel form of immunotherapy.

引用

页码：1379 / 1388

页数：10

共 127 条

[51]

Ishihara S, 1999, EUR J IMMUNOL, V29, P2406, DOI 10.1002/(SICI)1521-4141(199908)29:08<2406::AID-IMMU2406>3.3.CO

[52]

2-6

[53] Involvement of decidual Vα14 NKT cells in abortion [J].

Ito, K ;

Karasawa, M ;

Kawano, T ;

Akasaka, T ;

Koseki, H ;

Akutsu, Y ;

Kondo, E ;

Sekiya, S ;

Sekikawa, K ;

Harada, M ;

Yamashita, M ;

Nakayama, T ;

Taniguchi, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (02) :740-744

[54] Activation of natural killer T cells potentiates or prevents experimental autoimmune encephalomyelitis [J].

Jahng, AW ;

Maricic, I ;

Pedersen, B ;

Burdin, N ;

Naidenko, O ;

Kronenberg, M ;

Koezuka, Y ;

Kumar, V .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (12) :1789-1799

[55] NK T cells contribute to expansion of CD8+ T cells and amplification of antiviral immune responses to respiratory syncytial virus [J].

Johnson, TR ;

Hong, SM ;

Van Kaer, L ;

Koezuka, Y ;

Graham, BS .

JOURNAL OF VIROLOGY, 2002, 76 (09) :4294-4303

[56]

Kawano T, 1999, CANCER RES, V59, P5102

[57] CD1d-restricted and TCR-mediated activation of V(alpha)14 NKT cells by glycosylceramides [J].

Kawano, T ;

Cui, JQ ;

Koezuka, Y ;

Toura, I ;

Kaneko, Y ;

Motoki, K ;

Ueno, H ;

Nakagawa, R ;

Sato, H ;

Kondo, E ;

Koseki, H ;

Taniguchi, M .

SCIENCE, 1997, 278 (5343) :1626-1629

[58] NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells [J].

Kenna, T ;

Mason, LG ;

Porcelli, SA ;

Koezuka, Y ;

Hegarty, JE ;

O'Farrelly, C ;

Doherty, DG .

JOURNAL OF IMMUNOLOGY, 2003, 171 (04) :1775-1779

[59] In vitro anti-tumour activity of α-galactosylceramide-stimulated human invariant Vα24+NKT cells against melanoma [J].

Kikuchi, A ;

Nieda, M ;

Schmidt, C ;

Koezuka, Y ;

Ishihara, S ;

Ishikawa, Y ;

Tadokoro, K ;

Durrant, S ;

Boyd, A ;

Juji, T ;

Nicol, A .

BRITISH JOURNAL OF CANCER, 2001, 85 (05) :741-746

[60] Quantitation and phenotypic analysis of natural killer T cells in primary biliary cirrhosis using a human mid tetramer [J].

Kita, H ;

Naidenko, OV ;

Kronenberg, M ;

Ansari, AA ;

Rogers, P ;

He, XS ;

Koning, F ;

Mikayama, T ;

Van de Water, J ;

Coppel, RL ;

Kaplan, M ;

Gershwin, ME .

GASTROENTEROLOGY, 2002, 123 (04) :1031-1043

← 1 2 3 4 5 6 7 8 9 10 →