Himastatin, a new antitumor antibiotic from Streptomyces hygroscopicus .3. Structural elucidation

被引：49

作者：

Leet, JE

Schroeder, DR

Golik, J

Matson, JA

Doyle, TW

Lam, KS

Hill, SE

Lee, MS

Whitney, JL

Krishnan, BS

机构：

[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, Wallingford

来源：

JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 03期

关键词：

D O I：

10.7164/antibiotics.49.299

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The structure of the antitumor antibiotic himastatin was determined using a combination of spectroscopic and chemical degradation techniques. Himastatin is a unique dimeric cyclohexadepsipeptide joined through a biphenyl linkage between two oxidized tryptophan units. The gross structure of the dimer was established through degradative ozonolysis. Himastatin consists of D-valine, D-threonine, L-leucine, L-alpha-hydroxyisovaleric acid, (3R,5R)-5-hydroxypiperazic acid, and (2R,3aR,8aR)-3a-hydroxyhexahydropyrrolo[2,3b]indole 2-carboxylic acid subunits.

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页码：299 / 311

页数：13

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