Left bundle branch block as a risk factor for progression to heart failure

被引：143

作者：

Zannad, Faiez

Huvelle, Etienne

Dickstein, Kenneth

van Veldhuisen, Dirk J.

Stellbrink, Christoph

Kober, Lars

Cazeau, Serge

Ritter, Philippe

Maggioni, Aldo Pietro

Ferrari, Roberto

Lechat, Philippe

机构：

[1] INSERM, CIC, CHU Nancy, Hop Jean Arc, F-54201 Toul, France

[2] Guidant CRM, Dept Clin Res, Brussels, Belgium

[3] Stavanger Univ Hosp, Dept Cardiol, Stavanger, Norway

[4] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands

[5] Univ Hosp, RWTH, Dept Cardiol, Aachen, Germany

[6] Rigshosp, Ctr Heart, Dept Cardiol, DK-2100 Copenhagen, Denmark

[7] InParys, Dept Cardiol, St Cloud, France

[8] ANMCO Res Ctr, Florence, Italy

[9] Univ Ferrara, Dept Cardiol, I-44100 Ferrara, Italy

[10] IRCCS, Salvatore Maugeri Fdn, Cardiovasc Res Ctr, Gussago, Italy

[11] Hop La Pitie Salpetriere, Clin Pharmacol Dept, Paris, France

来源：

EUROPEAN JOURNAL OF HEART FAILURE | 2007年 / 9卷 / 01期

关键词：

left bundle branch block; remodelling; heart failure; prevention; cardiac resynchronisation therapy; CARDIAC RESYNCHRONIZATION THERAPY; ACUTE MYOCARDIAL-INFARCTION; CORONARY-ARTERY-DISEASE; NEWLY ACQUIRED LEFT; INDEPENDENT PREDICTOR; VENTRICULAR RESYNCHRONIZATION; DILATED CARDIOMYOPATHY; QRS DURATION; ACTIVATION; POPULATION;

D O I：

10.1016/j.ejheart.2006.04.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The prevalence of conduction disturbances, particularly left bundle branch block (LBBB), is strongly correlated with age and with the presence of cardiovascular disease. LBBB has been reported to affect approximately 25% of the heart failure (HF) population and it is likely that the deleterious role of such conduction disorders in the progression to HF has been underestimated. The purpose of this article is to review the data from the literature indicating that LBBB may have a causative role, mediated through the resulting intra-ventricular asynchrony, in the deterioration of cardiac function and the development of cardiac remodelling and HE It also aims to address the potential for future clinical therapies for this conduction disorder. (c) 2006 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

引用

页码：7 / 14

页数：8

共 56 条

[1] Effects of cardiac resynchronization on disease progression in patients with left ventricular systolic dysfunction, an indication for an implantable cardioverter-defibrillator, and mildly symptomatic chronic heart failure [J].