Complexity in Influenza Virus Targeted Drug Design: Interaction with Human Sialidases

被引：61

作者：

Chavas, Leonard M. G. ^{[1
]}

Kato, Ryuichi ^{[1
]}

Suzuki, Nobuhiro ^{[1
]}

von Itzstein, Mark ^{[2
]}

Mann, Maretta C. ^{[2
]}

Thomson, Robin J. ^{[2
]}

Dyason, Jeffrey C. ^{[2
]}

McKimm-Breschkin, Jennifer

Fusi, Paola ^{[3
]}

Tringali, Cristina ^{[3
]}

Venerando, Bruno ^{[3
]}

Tettamanti, Guido ^{[4
]}

Monti, Eugenio ^{[5
]}

Wakatsuki, Soichi ^{[1
]}

机构：

[1] PF IMSS KEK SBRC, Tsukuba, Ibaraki 3050801, Japan

[2] Griffith Univ, Nathan, Qld 4111, Australia

[3] Univ Milano Bicocca, Milan, Italy

[4] Univ Milan, Milan, Italy

[5] Univ Brescia, Brescia, Italy

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 53卷 / 07期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

HUMAN CYTOSOLIC SIALIDASE; NEURAMINIDASE INHIBITOR; OSELTAMIVIR; DISCOVERY; ZANAMIVIR; POTENT; ACID;

D O I：

10.1021/jm100078r

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

With the global spread of the pandemic H1N1 and the ongoing pandemic potential of the H5N1 subtype, the influenza virus represents one of the most alarming viruses spreading worldwide. The influenza virus sialidase is an effective drug target, and a number of inhibitors are clinically effective against the virus (zanamivir, oseltamivir, peramivir). Here we report structural and biochemical studies of the human cytosolic sialidase Neu2 with influenza virus sialidase-targeting drugs and related compounds.

引用

页码：2998 / 3002

页数：5

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