Cumulating evidence from randomized trials: Utilizing sequential monitoring boundaries for cumulative meta-analysis

被引：286

作者：

Pogue, JM

Yusuf, S

机构：

[1] MCMASTER UNIV, DEPT CLIN EPIDEMIOL & BIOSTAT, HAMILTON, ON, CANADA

[2] MCMASTER UNIV, DIV CARDIOL, HAMILTON, ON, CANADA

来源：

CONTROLLED CLINICAL TRIALS | 1997年 / 18卷 / 06期

关键词：

meta-analysis; randomized controlled trials; stochastic processes; myocardial infarction; magnesium; streptokinase; thrombolytic therapy;

D O I：

10.1016/S0197-2456(97)00051-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We propose the adaptation of classical monitoring boundaries for use in cumulative meta-analysis as guidelines for deciding when accumulating evidence is statistically significant and medically convincing. The interpretation of information from a randomized controlled trial is compared with that from a meta-analysis. The concept of optimal information size for a meta-analysis is developed and used to adapt monitoring boundaries to cumulative meta-analysis. (C) Elsevier Science Inc. 1997.

引用

页码：580 / 593

页数：14

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