The World Health Organization classification of malignant lymphomas in Japan: Incidence of recently recognized entities

被引：271

作者：

Fujita, M

Yamashiro, K

Ichinohasama, R

Nakamura, N

Abe, M

Wakasa, H

Kojima, M

Motoori, T

Izumo, T

Tamaru, J

Mikata, A

Takeuchi, K

Kakiuchi, C

Mori, S

Matsuno, Y

Nakamura, S

Yatabe, Y

Ichimura, K

Suchi, T

Tajima, K

Mori, N

Takasaki, K

Tsurumi, K

Takami, T

Haga, H

Sakurai, T

Yamabe, H

Kobashi, Y

Ohsawa, M

Kanno, H

Aozasa, K

Nakamine, H

Yoshino, T

Akagi, T

Sasaki, N

Namba, K

Agatsuma, Y

Iwata, K

Suzumiya, J

Ohshima, K

Kikuchi, M

Takeshita, M

Hasui, K

Sato, E

Sueyoshi, K

Tokunaga, M

机构：

[1] Sapporo Natl Hosp, Dept Clin Res, Sapporo, Hokkaido, Japan

[2] Tohoku Univ, Sch Dent, Dept Oral Pathol, Sendai, Miyagi 980, Japan

[3] Fukushima Med Univ, Sch Med, Dept Pathol, Fukushima, Japan

[4] Dokkyo Univ, Sch Med, Dept Pathol, Mibu, Tochigi, Japan

[5] Kitasato Inst, Med Ctr Hosp, Dept Pathol, Kitamoto, Japan

[6] Saitama Canc Ctr, Dept Pathol, Ina, Saitama, Japan

[7] Saitama Med Sch, Saitama Med Ctr, Dept Pathol, Kawagoe, Saitama, Japan

[8] Chiba Univ, Dept Pathol, Chiba, Japan

[9] Univ Tokyo, Fac Med, Dept Pathol, Tokyo 113, Japan

[10] Univ Tokyo, Inst Med Sci, Dept Pathol, Tokyo, Japan

[11] Natl Canc Ctr, Dept Pathol, Tokyo 104, Japan

[12] Aichi Canc Ctr, Dept Pathol & Genet, Nagoya, Aichi 464, Japan

[13] Aichi Canc Ctr, Res Inst, Div Epidemiol, Nagoya, Aichi 464, Japan

[14] Nagoya Univ, Sch Med, Dept Pathol, Nagoya, Aichi 466, Japan

[15] Gifu Univ, Sch Med, Dept Pathol, Gifu 500, Japan

[16] Kyoto Univ Hosp, Anat Pathol Lab, Kyoto 606, Japan

[17] Tenri Hosp, Dept Pathol, Nara, Japan

[18] Osaka Univ, Sch Med, Dept Pathol, Osaka 530, Japan

[19] Wakayama Univ, Sch Med, Dept Clin Lab Med, Wakayama, Japan

[20] Okayama Univ, Sch Med, Dept Pathol, Okayama 700, Japan

[21] Kure Kyosai Hosp, Dept Pathol, Hiroshima, Japan

[22] Hiroshima Univ, Fac Integrated Arts & Sci, Hiroshima 730, Japan

[23] Kochi Prefectural Hosp, Dept Pathol, Kochi, Japan

[24] Fukuoka Univ, Sch Med, Dept Pathol, Fukuoka 81401, Japan

[25] Natl Kyushu Med Ctr Hosp, Dept Pathol, Fukuoka, Japan

[26] Kagoshima Univ, Sch Med, Dept Pathol, Kagoshima 890, Japan

[27] Kagoshima City Hosp, Dept Pathol, Kagoshima, Japan

[28] Kagoshima Univ, Sch Med, Dept Publ Hlth, Kagoshima 890, Japan

来源：

PATHOLOGY INTERNATIONAL | 2000年 / 50卷 / 09期

关键词：

disease entities; incidence; Japan; malignant lymphoma; WHO classification;

D O I：

10.1046/j.1440-1827.2000.01108.x

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

New insights into the immunology and genetics of malignant lymphomas have allowed the recognition of new entities and the refinement of previously recognized disease categories. The relative incidence of these subtypes of malignant lymphoma is also known to differ according to geographic location. In order to clarify the current status of malignant lymphomas in Japan and the relative incidences of their subtypes, 3194 patients were classified according to the new World Health Organization (WHO) classification. Among these were 3025 cases (94.71%) of non-Hodgkin's lymphoma (2189 cases (68.53%) of B-cell lymphoma, 796 cases (24.92%) of T-cell lymphoma) and 141 cases (4.41%) of Hodgkin's lymphoma. The incidences of the major subtypes of non-Hodgkin's lymphoma were 33.34% for diffuse large B-cell lymphoma, 8.45% for marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type, 8.05% for plasma cell myeloma, 7.45% for adult T-cell leukemia/lymphoma (ATLL), 6.7% for follicular lymphoma, 6.67% for peripheral T-cell lymphoma of unspecified type, 2.79% for mantle cell lymphoma, 2.6% for nasal and nasal-type T/NK cell lymphoma, 2.35% for angioimmunoblastic T-cell lymphoma, and 2.35% for precursor B-cell lymphoblastic leukemia/lymphoma, in decreasing order. The other subtypes comprised less than 2%, mainly precursor T-cell lymphoblastic lymphoma/leukemia (1.72%), anaplastic large-cell lymphoma of T- and null-cell types (1.53%), and B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (1.31%). The incidence of ATLL was influenced by its high percentage (19.20%) in the south-western Japanese island, Kyushu, an endemic area of human T-cell leukemia virus type 1 (HTLV-1), but which appeared to be lower than that in a previous study. The nodular sclerosis and mixed cellularity types of Hodgkin's disease occupied 1.78% and 1.63%, respectively. These data are distinct from those in Western countries and similar in several ways to those in the East, although the relatively high rate of ATLL was attributed to the geographical difference in the etiologic factor, HTLV-1.

引用

页码：696 / 702

页数：7

共 39 条

[11]

2-A

[12] Clinicopathological evaluation of the Revised European-American Classification of Lymphoid Neoplasms (REAL) in Japan [J].