Angiogenesis: What can it offer for future medicine?

被引：43

作者：

Cao, Yihai ^{[1
]}

机构：

[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, S-17177 Stockholm, Sweden

来源：

EXPERIMENTAL CELL RESEARCH | 2010年 / 316卷 / 08期

基金：

欧洲研究理事会; 瑞典研究理事会;

关键词：

Angiogenesis; Cancer; Targeted therapy; Ocular disease; Cardiovascular disease; ARTERIOGENIC FACTORS; BEVACIZUMAB; RANIBIZUMAB; COMBINATION; SUNITINIB; CANCER; IMPROVEMENT; ZEBRAFISH; INHIBITOR; THERAPY;

D O I：

10.1016/j.yexcr.2010.02.031

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Modulation of angiogenesis for disease therapy was proposed nearly 40 years ago and today various protein and chemical molecules are available for the treatment of human malignant and ophthalmological disorders. Angiogenesis research has emerged, as one of the most comprehensive research areas, in biomedicine and development of novel drugs by targeting angiogenesis has become one of the main focuses among pharmaceutical giants. If 30% of annually 12 million new cancer cases worldwide receive antiangiogenic therapy, over 60 million cancer patients would be treated by the end of 2060. In this mini-review, I discuss current available antiangiogenic drugs and future therapeutic options based on the angiogenesis principle. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：1304 / 1308

页数：5

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