[3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy:: Potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor

被引：125

作者：

Cosford, NDP

Roppe, J

Tehrani, L

Schweiger, EJ

Seiders, TJ

Chaudary, A

Rao, S

Varney, MA

机构：

[1] Merck Res Labs, Dept Chem, MRLSDB2, San Diego, CA 92121 USA

[2] Merck Res Labs, Dept Neuropharmacol, MRLSDB1, San Diego, CA 92121 USA

[3] Merck Res Labs, Dept Drug Metab, Rahway, NJ 07065 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(02)00997-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The design, synthesis, and characterization of two potent, non-competitive radioligands, [H-3]-methoxymethyl-MTEP and [H-3]-methoxy-PEPy, that are selective for the mGlu5 receptor are described. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：351 / 354

页数：4

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