Synthetic biology: applications come of age

被引：929

作者：

Khalil, Ahmad S. ^{[1
,2
]}

Collins, James J. ^{[1
,2
,3
]}

机构：

[1] Boston Univ, Dept Biomed Engn, Howard Hughes Med Inst, Ctr Biodynam, Boston, MA 02215 USA

[2] Boston Univ, Ctr Adv Biotechnol, Boston, MA 02215 USA

[3] Harvard Univ, Wyss Inst Biologically Inspired Engn, Boston, MA 02115 USA

来源：

NATURE REVIEWS GENETICS | 2010年 / 11卷 / 05期

基金：

美国国家卫生研究院;

关键词：

EUKARYOTIC GENE-EXPRESSION; INVERSION RECOMBINATION SWITCH; MAMMALIAN-CELLS; ESCHERICHIA-COLI; CLOSTRIDIUM-ACETOBUTYLICUM; SPATIOTEMPORAL CONTROL; TRANSGENE EXPRESSION; REGULATED EXPRESSION; POLYKETIDE SYNTHASE; RNA THERMOSENSOR;

D O I：

10.1038/nrg2775

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Synthetic biology is bringing together engineers and biologists to design and build novel biomolecular components, networks and pathways, and to use these constructs to rewire and reprogram organisms. These re-engineered organisms will change our lives over the coming years, leading to cheaper drugs, 'green' means to fuel our cars and targeted therapies for attacking 'superbugs' and diseases, such as cancer. The de novo engineering of genetic circuits, biological modules and synthetic pathways is beginning to address these crucial problems and is being used in related practical applications.

引用

页码：367 / 379

页数：13

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