CALHM1 P86L Polymorphism is a Risk Factor for Alzheimer's Disease in the Chinese Population

被引：23

作者：

Cui, Pei-Jing ^{[1
]}

Zheng, Lan ^{[1
]}

Cao, Li ^{[1
]}

Wang, Ying ^{[1
]}

Deng, Yu-Lei ^{[1
]}

Wang, Gang ^{[1
]}

Xu, Wei ^{[1
]}

Tang, Hui-Dong ^{[1
]}

Ma, Jian-Fang ^{[1
]}

Zhang, Ting ^{[1
]}

Ding, Jian-Qing ^{[1
]}

Cheng, Qi ^{[4
]}

Chen, Sheng-Di ^{[1
,2
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Neurol, Shanghai 200025, Peoples R China

[2] Chinese Acad Sci, Lab Neurodegenerat Dis, Inst Hlth Sci, Shanghai Inst Biol Sci, Shanghai, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Shanghai 200025, Peoples R China

[4] Shanghai Jiao Tong Univ, Sch Publ Hlth, Shanghai 200025, Peoples R China

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2010年 / 19卷 / 01期

关键词：

Alzheimer's disease; CALHM1; P86L; polymorphism; GENE;

D O I：

10.3233/JAD-2010-1207

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We conducted a case-control study to determine the prevalence of the CALHM1 P86L polymorphism (rs2986017) in patients with Alzheimer's disease (AD) in the Chinese population of mainland China, and also to clarify whether this polymorphism is a risk factor for AD. Fourteen heterozygous P86L carriers were identified among 198 AD patients. One control subject was also found to be a P86L heterozygous carrier. The allelic frequencies of the AD patients and control subjects were found to be significantly different. Our study indicates that the CALHM1-P86L polymorphism is associated with AD in the ethnic Chinese Han.

引用

页码：31 / 35

页数：5

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