Interferon-beta and interferon-gamma synergistically inhibit the replication of severe acute respiratory syndrome-associated coronavirus (SARS-CoV)

被引：143

作者：

Sainz, B

Mossel, EC

Peters, CJ

Garry, RF

机构：

[1] Univ Texas, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

[2] Tulane Univ, Hlth Sci Ctr, Dept Microbiol & Immunol, Program Mol Pathogenesis & Immun, New Orleans, LA 70112 USA

[3] Univ Texas, Med Branch, Dept Pathol, Galveston, TX 77555 USA

来源：

VIROLOGY | 2004年 / 329卷 / 01期

关键词：

coronavirus; interferon-gamma; interferon-beta;

D O I：

10.1016/j.virol.2004.08.011

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Recent studies have shown that interferon-gamma (IFN-gamma) synergizes with IFN-alpha/beta to inhibit the replication of both RNA and DNA viruses. We investigated the effects of IFNs on the replication of two strains of severe acute respiratory syndrome-associated coronavirus (SARS-CoV). While treatment of Vero E6 cells with 100 U/ml of either IFN-beta or IFN-gamma marginally reduced viral replication, treatment with both IFN-beta and IFN-gamma inhibited SARS-CoV plaque formation by 30-fold and replication by 3000-fold at 24 h and by > 1 X 10(5)-fold at 48 and 72 h post-infection. These studies suggest that combination IFN treatment warrants further investigation as a treatment for SARS. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：11 / 17

页数：7

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