Epigenetic changes: Potential therapeutic targets

被引：26

作者：

Kalebic, T ^{[1
]}

机构：

[1] NCI, Lung & Upper Aerodigest Canc Res Grp, Div Canc Prevent, Bethesda, MD 20892 USA

来源：

EPIGENETICS IN CANCER PREVENTION: EARLY DETECTION AND RISK ASSESSMENT | 2003年 / 983卷

关键词：

methylation; acetylation; cancer; markers; clinical treatment;

D O I：

10.1111/j.1749-6632.2003.tb05982.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent advances in human genome research have resulted in novel approaches for the identification of epigenetic modifications associated with cancer. Modulators of DNA methylation and chromatin structure have a dramatic effect on gene expression, cellular proliferation, differentiation, and apoptosis. Molecular pathways regulating epigenetic events that occur during tumorigenesis have been exploited as new targets for therapeutic intervention. Clinical studies exploring the effectiveness of therapeutic agents targeting DNA methylation and acetylation of histones have yielded promising results. Molecular profiles of epigenetic alterations in cancer cells could allow better stratification of patients who may show responsiveness to specific treatments.

引用

页码：278 / 285

页数：8

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