Identification and efficacy of longitudinal markers for survival

被引：57

作者：

Henderson, R ^{[1
]}

Diggle, P ^{[1
]}

Dobson, A ^{[1
]}

机构：

[1] Univ Lancaster, Med Stat Unit, Lancaster LA1 4YF, England

来源：

BIOSTATISTICS | 2002年 / 3卷 / 01期

关键词：

explained variation; joint modelling; residual lifetime distribution; score test; surrogates;

D O I：

10.1093/biostatistics/3.1.33

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Methods for the combined analysis of survival time and longitudinal biomarker data have been developed in recent years, with most emphasis on modelling and estimation. This paper focuses on the use of longitudinal marker trajectories as individual-level surrogates for survival. A score test for association which requires only standard methods for implementation is derived for the initial identification of candidate biomarkers. Methods for assessing efficacy of markers are discussed and a measure contrasting conditional and marginal distibutions is proposed. An application using prothrombin index as biomarker for survival of liver cirrhosis patients is included.

引用

页码：33 / 50

页数：18

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