Immunoglobulin G Antibody Against Helicobacter pylori Is an Accurate Test for Atrophic Gastritis

被引:10
作者
Hung, Hung-Hsu [1 ]
Chen, Tseng-Shing [1 ,2 ]
Lin, Han-Chieh [1 ,2 ]
机构
[1] Taipei Vet Gen Hosp, Dept Med, Div Gastroenterol, Taipei 112, Taiwan
[2] Natl Yang Ming Univ, Sch Med, Fac Med, Taipei 112, Taiwan
关键词
atrophic gastritis; Helicobacter pylori; serology test; ERADICATION THERAPY; BREATH TEST; INFECTION; DIAGNOSIS; SEROLOGY; SERUM; MANAGEMENT; POPULATION; HISTOLOGY; CANCER;
D O I
10.1016/S1726-4901(10)70077-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Enzyme-linked immunosorbent assay (ELISA) is the most commonly used serologic test for Helicobacter pylori. This study aimed to investigate the effects of age and atrophic gastritis on the diagnostic accuracy of an immunoglobulin G (IgG) antibody test against H. pylori in adults. Methods: One hundred and seventy dyspeptic patients (age range, 20-70 years) were evaluated. H. pylori infection was diagnosed when culture or both urease and histological tests were positive. Serum pepsinogen-I (P-I) and pepsinogen-II (P-II) levels were measured. Atrophic gastritis was defined when P-I <= 70 mu g/L and P-I/P-II <= 3. A quantitative ELISA test (HEL-pTEST II) was used for IgG antibodies against H. pylori. Results: The H. pylori prevalence rate was 62.1%. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of ELISA were 93.5%, 94.4%, 95.6%, 91.9%, and 93.9% in patients aged <45 years, and 100%, 81.3%, 94.3%, 100%, and 95.6% in patients aged >= 45 years, respectively. Twenty-six patients had atrophic gastritis. There was 100% sensitivity and 86.7% specificity in atrophic gastritis and 96.5% sensitivity and 91.9% specificity in non-atrophic gastritis. Conclusion: The quantitative ELISA test is a good noninvasive test even in older age groups and is a suitable test in patients with atrophic gastritis due to its excellent sensitivity. [J Chin Med Assoc 2010;73(7):355-359]
引用
收藏
页码:355 / 359
页数:5
相关论文
共 35 条
[11]   Serological methods for diagnosis of Helicobacter pylori infection and monitoring of eradication therapy [J].
Herbrink, P ;
van Doorn, LJ .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2000, 19 (03) :164-173
[12]   EVALUATION OF THE PERFORMANCE OF COMMERCIAL TEST KITS FOR DETECTION OF HELICOBACTER-PYLORI ANTIBODIES IN SERUM [J].
HOEK, FJ ;
NOACH, LA ;
RAUWS, EAJ ;
TYTGAT, GNJ .
JOURNAL OF CLINICAL MICROBIOLOGY, 1992, 30 (06) :1525-1528
[13]   POSITIVE SERUM ANTIBODY AND NEGATIVE TISSUE-STAINING FOR HELICOBACTER-PYLORI IN SUBJECTS WITH ATROPHIC BODY GASTRITIS [J].
KARNES, WE ;
SAMLOFF, IM ;
SIURALA, M ;
KEKKI, M ;
SIPPONEN, P ;
KIM, SWR ;
WALSH, JH .
GASTROENTEROLOGY, 1991, 101 (01) :167-174
[14]   Positive result by serology indicates active Helicobacter pylori infection in patients with atrophic gastritis [J].
Kokkola, A ;
Rautelin, H ;
Puolakkainen, P ;
Sipponen, P ;
Färkkilä, M ;
Haapiainen, R ;
Kosunen, TU .
JOURNAL OF CLINICAL MICROBIOLOGY, 1998, 36 (06) :1808-1810
[15]  
Kokkola A, 2000, SCAND J GASTROENTERO, V35, P138, DOI 10.1080/003655200750024290
[16]   Analysis of eight different methods for the detection of Helicobacter pylori infection in patients with dyspepsia [J].
Kullavanijaya, P ;
Thong-Ngam, D ;
Hanvivatvong, O ;
Nunthapisud, P ;
Tangkijvanich, P ;
Suwanagool, P .
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2004, 19 (12) :1392-1396
[17]  
Lehours P, 2003, AM J GASTROENTEROL, V98, P291, DOI [10.1016/S0002-9270(02)05932-4, 10.1111/j.1572-0241.2003.t01-1-07264.x]
[18]   The Validity of a Biomarker Method for Indirect Detection of Gastric Mucosal Atrophy Versus Standard Histopathology [J].
Leja, Marcis ;
Kupcinskas, Limas ;
Funka, Konrads ;
Sudraba, Agnese ;
Jonaitis, Laimas ;
Ivanauskas, Audrius ;
Janciauskas, Dainius ;
Kiudelis, Gediminas ;
Chiu, Han-Mo ;
Lin, Jaw-Town .
DIGESTIVE DISEASES AND SCIENCES, 2009, 54 (11) :2377-2384
[19]  
Lerang F, 1998, SCAND J GASTROENTERO, V33, P364, DOI 10.1080/00365529850170982
[20]   Epidemiology of Helicobacter pylori infection [J].
Malaty, Hoda M. .
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 2007, 21 (02) :205-214