ABC transporters in cancer: more than just drug efflux pumps

被引：855

作者：

Fletcher, Jamie I. ^{[1
]}

Haber, Michelle ^{[1
]}

Henderson, Michelle J. ^{[1
]}

Norris, Murray D. ^{[1
]}

机构：

[1] Univ New S Wales, Lowry Canc Res Ctr, Childrens Canc Inst Australia Med Res, Randwick, NSW 2031, Australia

来源：

NATURE REVIEWS CANCER | 2010年 / 10卷 / 02期

基金：

英国医学研究理事会;

关键词：

MULTIDRUG-RESISTANCE PROTEIN; PLATELET-ACTIVATING-FACTOR; BINDING-CASSETTE TRANSPORTERS; PROSTAGLANDIN E-2 TRANSPORT; ATP-DEPENDENT TRANSPORT; STEM-LIKE CELLS; P-GLYCOPROTEIN; GENE-EXPRESSION; SIDE POPULATION; LEUKEMIA-CELLS;

D O I：

10.1038/nrc2789

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Multidrug transporter proteins are best known for their contributions to chemoresistance through the efflux of anticancer drugs from cancer cells. However, a considerable body of evidence also points to their importance in cancer extending beyond drug transport to fundamental roles in tumour biology. Currently, much of the evidence for these additional roles is correlative and definitive studies are needed to confirm causality. We propose that delineating the precise roles of these transporters in tumorigenesis and treatment response will be important for the development of more effective targeted therapies.

引用

收藏

页码：147 / 156

页数：10

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共 185 条

[71] Reversal of drug resistance in ovarian cancer: Where do we go from here? [J].

Kaye, Stan B. .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (16) :2616-2618

[72] Sequence analysis of twin ATP binding cassette proteins involved in translational control, antibiotic resistance, and ribonuclease L inhibition [J].

Kerr, ID .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 315 (01) :166-173

[73] Involvement of cholesterol-rich lipid rafts in interleukin-6-induced neuroendocrine differentiation of LNCaP prostate cancer cells [J].

Kim, JY ;

Adam, RM ;

Solomon, KR ;

Freeman, MR .

ENDOCRINOLOGY, 2004, 145 (02) :613-619

[74] Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3 [J].

Kimura, T ;

Watanabe, T ;

Sato, K ;

Kon, J ;

Tomura, H ;

Tamama, K ;

Kuwabara, A ;

Kanda, T ;

Kobayashi, I ;

Ohta, H ;

Ul, M ;

Okajima, F .

BIOCHEMICAL JOURNAL, 2000, 348 (pt 1) :71-76

[75] Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors [J].

Kluk, MJ ;

Hla, T .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2002, 1582 (1-3) :72-80

[76] Small molecules that dramatically alter multidrug resistance phenotype by modulating the substrate specificity of P-glycoprotein [J].

Kondratov, RV ;

Komarov, PG ;

Becker, Y ;

Ewenson, A ;

Gudkov, AV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (24) :14078-14083

[77] Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinoma [J].

König, J ;

Hartel, M ;

Nies, AT ;

Martignoni, ME ;

Guo, JC ;

Büchler, MW ;

Friess, H ;

Keppler, D .

INTERNATIONAL JOURNAL OF CANCER, 2005, 115 (03) :359-367

[78] In vitro and in vivo downregulation of MRP1 by antisense oligonucleotides:: A potential role in neuroblastoma therapy [J].

Kuss, BJ ;

Corbo, M ;

Lau, WM ;

Fennell, DA ;

Dean, NM ;

Cotter, FE .

INTERNATIONAL JOURNAL OF CANCER, 2002, 98 (01) :128-133

[79] Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate [J].

Lee, MJ ;

Thangada, S ;

Claffey, KP ;

Ancellin, N ;

Liu, CH ;

Kluk, M ;

Volpi, M ;

Sha'afi, RI ;

Hla, T .

CELL, 1999, 99 (03) :301-312

[80] The cyclosporin PSC 833 increases survival and delays engraftment of human multidrug-resistant leukemia cells in xenotransplanted NOD-SCID mice [J].

Lehne, G ;

Sorensen, DR ;

Tjonnfjord, GE ;

Beiske, C ;

Hagve, TA ;

Rugstad, HE ;

Clausen, OPF .

LEUKEMIA, 2002, 16 (12) :2388-2394

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