Modularity of intrinsic disorder in the human proteome

被引:92
作者
Pentony, Melissa M. [2 ]
Jones, David T. [1 ]
机构
[1] UCL, Dept Comp Sci, Bioinformat Grp, London, England
[2] NYU, Dept Biol, Ctr Genom & Syst Biol, New York, NY 10003 USA
基金
英国生物技术与生命科学研究理事会;
关键词
intrinsic disorder; human proteome; protein function; protein domains; NATIVELY UNFOLDED PROTEINS; FUNCTIONAL ANTHOLOGY; UNSTRUCTURED PROTEINS; FLEXIBLE NETS; PREDICTION; DATABASE; DOMAINS; RECOGNITION; BIOLOGY; SERVER;
D O I
10.1002/prot.22504
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Predicting regions of disorder has become of increasing interest when determining protein structure and function. With similar to 33% of eukaryotic proteins having significant disordered regions, and an increasing occurrence of disorder in higher organisms, an analysis of the importance of disorder from an evolutionary perspective was clearly warranted. Focusing on the human proteome, we have studied how abundant disorder is and its relevance to protein function and structure. We have shown that disordered regions frequently appear to be independent functional units, and judged by complete association to certain protein domains, may be evolutionarily conserved. Our work also supports previous analyses on association between disorder and alternate splicing and provides support for the modularity of disorder by showing that with respect to splicing events, disordered regions frequently appear to be spliced as whole units.
引用
收藏
页码:212 / 221
页数:10
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