Selective anticancer activity of β-lactams derived from polyaromatic compound

被引：32

作者：

Banik, Bimal K. ^{[1
]}

Becker, Frederick F. ^{[2
]}

机构：

[1] Univ Texas Pan Amer, Dept Chem, Edinburg, TX 78539 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Mol Pathol, Unit 951, Houston, TX 77504 USA

来源：

MOLECULAR MEDICINE REPORTS | 2010年 / 3卷 / 02期

关键词：

anticancer agents; beta-lactams; polyaromatic compounds; selectivity; STAUDINGER-REACTION; IMINES; ENTRY;

D O I：

10.3892/mmr_00000257

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Currently available anticancer drugs are cytotoxic to normal as well as to neoplastic cells, therefore the synthesis of beta-lactams as new and novel anticancer agents is extremely significant. We previously developed synthetic methods for the preparation of beta-lactams and anticancer agents resulting from polyaromatic amines. There have also been reports on the synthesis and biological evaluation of novel racemic beta-lactams Lis anticancer agents. In cell cycle analysis, these compounds demonstrated a G2 blockage against sensitive tumor cell lilies. In the present Study, useful and selective biological activities of chrysene beta-lactams are described.

引用

页码：315 / 316

页数：2

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