Molecular action of androgens

被引：97

作者：

Gobinet, J

Poujol, N

Sultan, C ^{[1
]}

机构：

[1] CHU Montpellier, Hop Arnaud Villeneuve, Unite Endocrinol Gynecol Pediat, Serv Pediat 1, Montpellier, France

[2] CHU Montpellier, Hop Lapeyronie, Serv Hormonol Dev & Reprod, Montpellier, France

[3] INSERM, U439, F-34090 Montpellier, France

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2002年 / 198卷 / 1-2期

关键词：

androgen receptor; transcription factor; transactivation regulation; structure; cofactor;

D O I：

10.1016/S0303-7207(02)00364-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The androgen receptor (AR), which mediates androgen action in the cell, belongs to the superfamily of nuclear receptors, a large group of transcription factors. Recent studies have described how the AR acts on specific target genes. The receptor's specificity of action depends on its regulation at different levels: expression in the cells, ligand binding and DNA-specific sequence recognition by structurally conserved domains and regulation by transcriptional factors in an integrated response. We propose, here, an overview of recent works on the molecular regulation of androgen-dependent genes by AR. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

收藏

页码：15 / 24

页数：10

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