Acidic mammalian chitinase - a potential target for asthma therapy

被引：72

作者：

Donnelly, LE ^{[1
]}

Barnes, PJ ^{[1
]}

机构：

[1] Natl Heart & Lung Inst, London SW3 6LY, England

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2004年 / 25卷 / 10期

关键词：

D O I：

10.1016/j.tips.2004.08.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Recently, inhibition of acidic mammalian chitinase in a murine asthmatic model was reported to have a profound anti-inflammatory effect, leading to the suggestion that this enzyme might be a novel therapeutic target for T helper 2-driven diseases such as asthma. The mechanism of action of such an enzyme in asthma pathology is unclear but the enzyme appears to mediate interleukin 13-dependent responses in a STAT6-independent manner. This observation has led to the proposal that chitinase family members are important mediators in allergic diseases including asthma.

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页码：509 / 511

页数：3

相关论文

共 19 条

[1] CYTOCHEMICAL-LOCALIZATION OF CARBOHYDRATE RESIDUES IN MICROFILARIAE OF WUCHERERIA-BANCROFTI AND BRUGIA-MALAYI [J].

ARAUJO, ACG ;

SOUTOPADRON, T ;

DESOUZA, W .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1993, 41 (04) :571-578

[2] Identification of a novel acidic mammalian chitinase distinct from chitotriosidase [J].

Boot, RG ;

Blommaart, EFC ;

Swart, E ;

Ghauharali-van der Vlugt, K ;

Bijl, N ;

Moe, C ;

Place, A ;

Aerts, JMFG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (09) :6770-6778

[3] Strong induction of members of the chitinase family of proteins in atherosclerosis - Chitotriosidase and human cartilage gp-39 expressed in lesion macrophages [J].

Boot, RG ;

van Achterberg, TAE ;

van Aken, BE ;

Renkema, GH ;

Jacobs, MJHM ;

Aerts, JMFG ;

de Vries, CJM .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1999, 19 (03) :687-694

[4]

Cai GP, 1997, J CELL BIOCHEM, V67, P257, DOI 10.1002/(SICI)1097-4644(19971101)67:2<257::AID-JCB11>3.0.CO

[5]

2-C

[6] A macrophage protein, Ym1, transiently expressed during inflammation is a novel mammalian lectin [J].

Chang, NCA ;

Hung, SI ;

Hwa, KY ;

Kato, I ;

Chen, JE ;

Liu, CH ;

Chang, AC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (20) :17497-17506

[7] Genetic polymorphisms in molecules of innate immunity and susceptibility to infection with Wuchereria bancrofti in South India [J].

Choi, EH ;

Zimmerman, PA ;

Foster, CB ;

Zhu, S ;

Kumaraswami, V ;

Nutman, TB ;

Chanock, SJ .

GENES AND IMMUNITY, 2001, 2 (05) :248-253

[8] ANTIBIOTICS THAT INHIBIT FUNGAL CELL-WALL DEVELOPMENT [J].

DEBONO, M ;

GORDEE, RS .

ANNUAL REVIEW OF MICROBIOLOGY, 1994, 48 :471-497

[9] MARKED ELEVATION OF PLASMA CHITOTRIOSIDASE ACTIVITY - A NOVEL HALLMARK OF GAUCHER DISEASE [J].

HOLLAK, CEM ;

VANWEELY, S ;

VANOERS, MHJ ;

AERTS, JMFG .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (03) :1288-1292

[10]

Johansen JS, 1996, BRIT J RHEUMATOL, V35, P553