Acidic mammalian chitinase - a potential target for asthma therapy

被引：72

作者：

Donnelly, LE ^{[1
]}

Barnes, PJ ^{[1
]}

机构：

[1] Natl Heart & Lung Inst, London SW3 6LY, England

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2004年 / 25卷 / 10期

关键词：

D O I：

10.1016/j.tips.2004.08.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Recently, inhibition of acidic mammalian chitinase in a murine asthmatic model was reported to have a profound anti-inflammatory effect, leading to the suggestion that this enzyme might be a novel therapeutic target for T helper 2-driven diseases such as asthma. The mechanism of action of such an enzyme in asthma pathology is unclear but the enzyme appears to mediate interleukin 13-dependent responses in a STAT6-independent manner. This observation has led to the proposal that chitinase family members are important mediators in allergic diseases including asthma.

引用

收藏

页码：509 / 511

页数：3

相关论文

共 19 条

[11] Insect chitinases: Molecular biology and potential use as biopesticides [J].

Kramer, KJ ;

Muthukrishnan, S .

INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1997, 27 (11) :887-900

[12] Hygiene hypothesis: Fact or fiction? [J].

Liu, AH ;

Murphy, JR .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2003, 111 (03) :471-478

[13] Regulation of T helper type 2 cell immunity by interleukin-4 and interleukin-13 [J].

McKenzie, ANJ .

PHARMACOLOGY & THERAPEUTICS, 2000, 88 (02) :143-151

[14]

NEVILLE AC, 1976, J CELL SCI, V21, P73

[15] Cellular expression of murine Ym1 and Ym2, chitinase family proteins, as revealed by in situ hybridization and immunohistochemistry [J].

Nio, J ;

Fujimoto, W ;

Konno, A ;

Kon, Y ;

Owhashi, M ;

Iwanaga, T .

HISTOCHEMISTRY AND CELL BIOLOGY, 2004, 121 (06) :473-482

[16] Molecular cloning of a putative gastric chitinase in the toad Bufo japonicus [J].

Oshima, H ;

Miyazaki, R ;

Ohe, Y ;

Hayashi, H ;

Kawamura, K ;

Kikuyama, S .

ZOOLOGICAL SCIENCE, 2002, 19 (03) :293-297

[17] Identification of a novel eosinophil chemotactic cytokine (ECF-L) as a chitinase family protein [J].

Owhashi, M ;

Arita, H ;

Hayai, N .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (02) :1279-1286

[18] Acid stress in the pathology of asthma [J].

Ricciardolo, FLM ;

Gaston, B ;

Hunt, J .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2004, 113 (04) :610-619

[19] Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation [J].

Zhu, Z ;

Zheng, T ;

Homer, RJ ;

Kim, YK ;

Chen, NY ;

Cohn, L ;

Hamid, Q ;

Elias, JA .

SCIENCE, 2004, 304 (5677) :1678-1682