Physiological and pathological roles for microRNAs in the immune system

被引：1321

作者：

O'Connell, Ryan M. ^{[1
]}

Rao, Dinesh S. ^{[1
,2
]}

Chaudhuri, Aadel A. ^{[1
]}

Baltimore, David ^{[1
]}

机构：

[1] CALTECH, Div Biol, Pasadena, CA 91125 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2010年 / 10卷 / 02期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

ACUTE MYELOID-LEUKEMIA; T-REG-CELLS; BINDING PROTEIN; B-CELLS; POSTTRANSCRIPTIONAL REGULATION; DEPENDENT LOCALIZATION; TRANSCRIPTION FACTORS; EXPRESSION PROFILES; DOWN-REGULATION; MESSENGER-RNAS;

D O I：

10.1038/nri2708

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mammalian microRNAs (miRNAs) have recently been identified as important regulators of gene expression, and they function by repressing specific target genes at the post-transcriptional level. Now, studies of miRNAs are resolving some unsolved issues in immunology. Recent studies have shown that miRNAs have unique expression profiles in cells of the innate and adaptive immune systems and have pivotal roles in the regulation of both cell development and function. Furthermore, when miRNAs are aberrantly expressed they can contribute to pathological conditions involving the immune system, such as cancer and autoimmunity; they have also been shown to be useful as diagnostic and prognostic indicators of disease type and severity. This Review discusses recent advances in our understanding of both the intended functions of miRNAs in managing immune cell biology and their pathological roles when their expression is dysregulated.

引用

收藏

页码：111 / 122

页数：12

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