Putting the opium in poppy to sleep

被引：9

作者：

Memelink, J ^{[1
]}

机构：

[1] Leiden Univ, Clusius Lab, Inst Biol, NL-2333 AL Leiden, Netherlands

来源：

NATURE BIOTECHNOLOGY | 2004年 / 22卷 / 12期

关键词：

D O I：

10.1038/nbt1204-1526

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A genetically modified opium poppy produces a pharmaceutical precursor instead of morphine and codeine.

引用

页码：1526 / 1527

页数：2

共 9 条

[1] Colocalization of L-phenylalanine ammonia-lyase and cinnarnate 4-hydroxylase for metabolic channeling in phenylpropanoid biosynthesis [J].

Achnine, L ;

Blancaflor, EB ;

Rasmussen, S ;

Dixon, RA .

PLANT CELL, 2004, 16 (11) :3098-3109

[2] RNAi-mediated replacement of morphine with the nonnarcotic alkaloid reticuline in opium poppy [J].

Allen, RS ;

Millgate, AG ;

Chitty, JA ;

Thisleton, J ;

Miller, JAC ;

Fist, AJ ;

Gerlach, WL ;

Larkin, PJ .

NATURE BIOTECHNOLOGY, 2004, 22 (12) :1559-1566

[3] A tale of three cell types: Alkaloid biosynthesis is localized to sieve elements in opium poppy [J].

Bird, DA ;

Franceschi, VR ;

Facchini, PJ .

PLANT CELL, 2003, 15 (11) :2626-2635

[4] The cell and developmental biology of alkaloid biosynthesis [J].

De Luca, V ;

St Pierre, B .

TRENDS IN PLANT SCIENCE, 2000, 5 (04) :168-173

[5] Alkaloid biosynthesis in plants: Biochemistry, cell biology, molecular regulation, and metabolic engineering applications [J].

Facchini, PJ .

ANNUAL REVIEW OF PLANT PHYSIOLOGY AND PLANT MOLECULAR BIOLOGY, 2001, 52 :29-66

[6] Revealing the world of RNA interference [J].

Mello, CC ;

Conte, D .

NATURE, 2004, 431 (7006) :338-342

[7] ORCAnization of jasmonate - responsive gene expression in alkaloid metabolism [J].

Memelink, J ;

Verpoorte, R ;

Kijne, JW .

TRENDS IN PLANT SCIENCE, 2001, 6 (05) :212-219

[8] Molecular cloning and functional expression of codeinone reductase:: the penultimate enzyme in morphine biosynthesis in the opium poppy Papaver somniferum [J].

Unterlinner, B ;

Lenz, R ;

Kutchan, TM .

PLANT JOURNAL, 1999, 18 (05) :465-475

[9] Metabolic channeling in plants [J].

Winkel, BSJ .

ANNUAL REVIEW OF PLANT BIOLOGY, 2004, 55 :85-107

← 1 →