The Akt-GSK-3 signaling cascade in the actions of doparnine

被引:349
作者
Beaulieu, Jean-Martin [1 ]
Gainetdinov, Raul R. [1 ]
Caron, Marc G. [1 ]
机构
[1] Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA
关键词
D O I
10.1016/j.tips.2007.02.006
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Drugs that act on dopamine neurotransmission are important tools for the management of multiple neuropsychiatric disorders. Classically, dopamine receptors have been shown to regulate cAMP-PKA (protein kinase A) and Ca2+ pathways through G-protein-mediated signaling. However, it has become apparent that, in addition to this canonical action, D-2-class dopamine receptors can function through a protein kinase B (Akt)-GSK-3 (glycogen synthase kinase 3) signaling cascade. This novel signaling mode involves the multifunctional scaffolding protein beta-arrestin 2, which has a role in G-protein-coupled receptor (GPCR) desensitization. In this article, we provide an overview of how this dual function of components of the GPCR desensitization machinery relates to dopamine-receptor-mediated responses and we summarize recent insights into the relevance of the Akt-GSK-3 signaling cascade for the expression of dopamine-associated behaviors and the actions of dopaminergic drugs.
引用
收藏
页码:166 / 172
页数:7
相关论文
共 62 条
[31]   A nuclear function of β-arrestin1 in GPCR signaling:: Regulation of histone acetylation and gene transcription [J].
Kang, JH ;
Shi, YF ;
Xiang, B ;
Qu, B ;
Su, WJ ;
Zhu, M ;
Zhang, M ;
Bao, GB ;
Wang, FF ;
Zhang, XQ ;
Yang, RX ;
Fan, FJ ;
Chen, XQ ;
Pei, G ;
Ma, L .
CELL, 2005, 123 (05) :833-847
[32]   The effects of clozapine on the GSK-3-mediated signaling pathway [J].
Kang, UG ;
Seo, MS ;
Roh, MS ;
Kim, Y ;
Yoon, SC ;
Kim, YS .
FEBS LETTERS, 2004, 560 (1-3) :115-119
[33]   Atypical antipsychotics: New directions and new challenges in the treatment of schizophrenia [J].
Kapur, S ;
Remington, G .
ANNUAL REVIEW OF MEDICINE, 2001, 52 :503-517
[34]   Alteration in kinase activity but not in protein levels of protein kinase B and glycogen synthase kinase-3β in ventral prefrontal cortex of depressed suicide victims [J].
Karege, Felicien ;
Perroud, Nader ;
Burkhardt, Sandra ;
Schwald, Michele ;
Ballmann, Eladia ;
La Harpe, Romano ;
Malafosse, Alain .
BIOLOGICAL PSYCHIATRY, 2007, 61 (02) :240-245
[35]   A molecular mechanism for the effect of lithium on development [J].
Klein, PS ;
Melton, DA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (16) :8455-8459
[36]   Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning [J].
Lai, Wen-Sung ;
Xu, Bin ;
Westphal, Koen G. C. ;
Paterlini, Marta ;
Olivier, Berend ;
Pavlidis, Paul ;
Karayiorgou, Maria ;
Gogos, Joseph A. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (45) :16906-16911
[37]   β-arrestin/AP-2 interaction in G protein-coupled receptor internalization -: Identification of a β-arrestin binding site in β2-adaptin [J].
Laporte, SA ;
Miller, WE ;
Kim, KM ;
Caron, MG .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (11) :9247-9254
[38]   Transduction of receptor signals by β-arrestins [J].
Leftowitz, RJ ;
Shenoy, SK .
SCIENCE, 2005, 308 (5721) :512-517
[39]   In vivo regulation of glycogen synthase kinase-3β (GSK3β) by serotonergic activity in mouse brain [J].
Li, XH ;
Zhu, W ;
Roh, MS ;
Friedman, AB ;
Rosborough, K ;
Jope, RS .
NEUROPSYCHOPHARMACOLOGY, 2004, 29 (08) :1426-1431
[40]   Regulation of mouse brain glycogen synthase kinase-3 by atypical antipsychotics [J].
Li, Xiaohua ;
Rosborough, Kelley M. ;
Friedman, Ari B. ;
Zhu, Wawa ;
Roth, Kevin A. .
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2007, 10 (01) :7-19