NMR determination of the absolute configuration of chiral 1,2-and 1,3-diols

被引：18

作者：

Fukui, H ^{[1
]}

Fukushi, Y ^{[1
]}

Tahara, S ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Agr, Kita Ku, Sapporo, Hokkaido 0608589, Japan

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 21期

基金：

日本学术振兴会;

关键词：

absolute configuration; chirarity; diol; NMR; NOE;

D O I：

10.1016/S0040-4039(03)00845-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Each of the chiral 1,2- and 1,3-diols examined was derivatized exclusively to a single diastereomeric acetal by the use of a new axially chiral reagent, 2'-methoxy-1,1'-binaphthalene-8-carbaldehyde (MBC). The absolute configuration of the original 1,2- and 1,3-diols was determined by the NOE correlation between the proton signals of the reagent moiety and those of the diol moiety in the acetals. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：4063 / 4065

页数：3

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