A new VHR dual-specificity protein tyrosine phosphatase inhibitor from Dendrobium moniliforme

被引：17

作者：

Bae, EY

Oh, H

Oh, WK

Kim, MS

Kim, BS

Kim, BY

Sohn, CB

Osada, H

Ahn, JS

机构：

[1] KRIBB, Taejon 305333, South Korea

[2] Chungnam Natl Univ, Dept Food & Nutr, Taejon 305764, South Korea

[3] RIKEN, Inst Phys & Chem Res, Wako, Saitama 35101, Japan

来源：

PLANTA MEDICA | 2004年 / 70卷 / 09期

关键词：

D O I：

10.1055/s-2004-827238

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided fractionation of the EtOAc-soluble extract of Dendrobium moniliforme afforded a new phenanthraquinonetype metabolite, 7-hydroxy-5,6-dimetlioxy-1,4-phenanthrenequinione (1), along with the previously reported 5-hydroxy-3,7-dimethoxy-1,4-phenanthrenequinone (2). The structures of the compounds were identified mainly on the basis of MS and NMR data. Compound 1 inhibited VHR dual-specificity protein tyrosine phosphatase (DS-PTPase) activity in a dose-dependent manner, displaying an IC50 value of 3.0 +/- 0.2 muM.

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收藏

页码：869 / 870

页数：2

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