In vitro studies of insulin-like growth factor I and bone

被引：37

作者：

Conover, CA ^{[1
]}

机构：

[1] Mayo Clin & Mayo Fdn, Endocrine Res Unit, Rochester, MN 55905 USA

来源：

GROWTH HORMONE & IGF RESEARCH | 2000年 / 10卷

关键词：

insulin-like growth factor I; insulin-like growth factor-binding protein (IGFBP); IGFBP-4; and-5; IGFBP protease; osteoblast;

D O I：

10.1016/S1096-6374(00)80020-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

insulin-like growth factor I (IGF-I) stimulates osteoblastic cells in culture to proliferate and to synthesize bone matrix proteins. However, local IGF-I action is modulated by a family of IGF-binding proteins (IGFBPs) that, in turn, are modified by specific IGFBP proteases, All these components of the IGF-I regulatory system are present and operative in bone cells in vitro. (C) 2000 Harcourt Publishers Ltd.

引用

页码：107 / 110

页数：4