Rate-accelerated nonconventional amide synthesis in water: A practical catalytic aldol-surrogate reaction

被引：115

作者：

Cho, Seung Hwan

Chang, Sukbok ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Chem, CMDS, Taejon 305701, South Korea

[2] Korea Adv Inst Sci & Technol, Sch Mol Sci BK21, Taejon 305701, South Korea

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 11期

关键词：

beta-hydroxy amides; alkynes; azides; copper; water;

D O I：

10.1002/anie.200604358

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) An aldol alternative: Cu-catalyzed hydrative amide synthesis is significantly accelerated in aqueous cosolvent systems. Under environmentally friendly conditions and with N2 released as the single side product, a wide range of propargyl alcohols and sulfonyl azides react to provide β-hydroxy N-sulfonamides in good to excellent yields. Polyhydroxy amides could be synthesized stereoselectively, proving this as a new practical aldol-surrogate strategy. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1897 / 1900

页数：4

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