Analysis of DNA adducts by capillary methods coupled to mass spectrometry: a perspective

被引：51

作者：

Apruzzese, WA

Vouros, P ^{[1
]}

机构：

[1] Northeastern Univ, Dept Chem, Boston, MA 02115 USA

[2] Northeastern Univ, Barnett Inst, Boston, MA 02115 USA

来源：

JOURNAL OF CHROMATOGRAPHY A | 1998年 / 794卷 / 1-2期

关键词：

reviews; mass spectrometry; DNA adducts;

D O I：

10.1016/S0021-9673(97)00820-0

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The analysis of DNA adducts, important molecular biomarkers indicative of potential cellular damage by covalent attachment to DNA, is discussed. The paper focusses on a discussion of the current status in the analysis of DNA adducts via the use of capillary high-performance liquid chromatographic and capillary electrophoretic methods coupled to tandem mass spectrometry. (C) 1998 Elsevier Science B.V.

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页码：97 / 108

页数：12

相关论文

共 30 条

[11]

JACKIM E, 1990, HRC-J HIGH RES CHROM, V13, P195

[12] Nano electrospray combined with a quadrupole ion trap for the analysis of peptides and protein digests [J].

Korner, R ;

Wilm, M ;

Morand, K ;

Schubert, M ;

Mann, M .

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 1996, 7 (02) :150-156

[13]

Li DH, 1996, CANCER RES, V56, P287

[14] STRUCTURAL CHARACTERIZATION OF NATURAL NUCLEOSIDES BY MASS-SPECTROMETRY [J].

MCCLOSKEY, JA .

ACCOUNTS OF CHEMICAL RESEARCH, 1991, 24 (03) :81-88

[15] LIQUID-CHROMATOGRAPHY THERMOSPRAY MASS-SPECTROMETRY OF DNA ADDUCTS FORMED WITH MITOMYCIN-C, PORFIROMYCIN AND THIOTEPA [J].

MUSSER, SM ;

PAN, SS ;

CALLERY, PS .

JOURNAL OF CHROMATOGRAPHY, 1989, 474 (01) :197-207

[16]

Nath RG, 1996, CANCER RES, V56, P452

[17] P-32-LABELING TEST FOR DNA DAMAGE [J].

RANDERATH, K ;

REDDY, MV ;

GUPTA, RC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (10) :6126-6129

[18] DETERMINATION OF IN-VITRO FORMED DNA-ADDUCTS OF 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE USING CAPILLARY LIQUID-CHROMATOGRAPHY ELECTROSPRAY-IONIZATION TANDEM MASS-SPECTROMETRY [J].

RINDGEN, D ;

TURESKY, RJ ;

VOUROS, P .

CHEMICAL RESEARCH IN TOXICOLOGY, 1995, 8 (08) :1005-1013

[19] SYNTHESIS AND IDENTIFICATION OF BENZO[A]PYRENE-GUANINE NUCLEOSIDE ADDUCTS FORMED BY ELECTROCHEMICAL OXIDATION AND BY HORSERADISH-PEROXIDASE CATALYZED REACTION OF BENZO[A]PYRENE WITH DNA [J].

ROGAN, EG ;

CAVALIERI, EL ;

TIBBELS, SR ;

CREMONESI, P ;

WARNER, CD ;

NAGEL, DL ;

TOMER, KB ;

CERNY, RL ;

GROSS, ML .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (12) :4023-4029

[20] Detection and characterization of two major ethylated deoxyguanosine adducts by high performance liquid chromatography, electrospray mass spectrometry, and P-32-postlabeling. Development of an approach for detection of phosphotriesters [J].

Singh, R ;

Sweetman, GMA ;

Farmer, PB ;

Shuker, DEG ;

Rich, KJ .

CHEMICAL RESEARCH IN TOXICOLOGY, 1997, 10 (01) :70-77