FoxM1 dances with mitosis

被引：173

作者：

Costa, RH ^{[1
]}

机构：

[1] Univ Illinois, Coll Med, Dept Biochem & Mol Genet, Chicago, IL 60607 USA

来源：

NATURE CELL BIOLOGY | 2005年 / 7卷 / 02期

关键词：

D O I：

10.1038/ncb0205-108

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

The mammalian Forkhead Box M1 (FoxM1) protein, known for its function as a transcriptional regulator of G1/S progression, is also crucial for the G2/M transition. Some of its target genes are cyclin B, Cdc25B phosphatase, Aurora B kinase and Polo-like kinase. Furthermore, identification of the nuclear protein CENP-F as a transcriptional target of FoxM1 reveals how it can also regulate the spindle assembly checkpoint, thereby ensuring proper chromosome stability and segregation during mitosis.

引用

页码：108 / 110

页数：3

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