Fabrication of gelatin-siloxane fibrous mats via sol-gel and electrospinning procedure and its application for bone tissue engineering

被引：30

作者：

Ren, Lei ^{[1
,2
]}

Wang, Jun ^{[1
]}

Yang, Fang-Yu ^{[3
]}

Wang, Lin ^{[1
]}

Wang, Dong ^{[1
]}

Wang, Tian-Xiao ^{[1
]}

Tian, Miao-Miao ^{[1
]}

机构：

[1] Xiamen Univ, Dept Biomat, Biomed Engn Res Ctr, Coll Mat, Xiamen 361005, Peoples R China

[2] Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China

[3] Xiamen Univ, Zhong Shan Hosp, Div Neurosurg, Xiamen 361004, Peoples R China

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2010年 / 30卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Electrospinning; Tissue engineering; Microporous materials; Sol-gel growth; STEM-CELLS; STRUCTURAL EVOLUTION; OSTEOBLASTIC CELLS; HYDROXYAPATITE; HYBRID; NANOFIBERS; COMPOSITES; MORPHOLOGY; SCAFFOLDS; POLYMERS;

D O I：

10.1016/j.msec.2009.12.013

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

082905 [生物质能源与材料]; 100103 [病原生物学];

摘要：

Our strategy is to design and fabricate biomimetic and bioactive scaffolds that resemble the native extracellular matrix as closely as possible so as to create conducive living milieu that will induce cell to function naturally. In the present study, gelatin/siloxane (GS) hybrids were prepared by a sol-gel processing, and electrospinning technique was used to fabricate GS fibrous mats to support the growth of bone marrow-derived mesenchymal stem cells (BMSCs) for tissue engineering of bone. The results indicate that the porous structure and fiber size of the GS fibrous mats can be fine tuned by varying the viscosity of GS precursor solution. Additionally, the Ca2+-containing GS fibrous mats biomimetically deposited apatite in a simulated body fluid (SBF), as well as stimulating its BMSCs proliferation and differentiation in vitro, thereby dignifying its in vitro bioactivity. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：437 / 444

页数：8

共 45 条

[1]

Fabrication and in vitro characterization of porous biodegradable composites based on phosphate glasses and oligolactide-containing polymer networks [J].