Parkin: A multipurpose neuroprotective agent?

被引：92

作者：

Feany, MB

Pallanck, LJ

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Pathol, Boston, MA 02115 USA

[2] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA

来源：

NEURON | 2003年 / 38卷 / 01期

关键词：

D O I：

10.1016/S0896-6273(03)00201-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An autosomal recessive juvenile-onset form of Parkinson's disease (AR-JP) is caused by loss-of-function mutations of the parkin gene, which encodes a ubiquitin-protein ligase. Three recent reports demonstrate that parkin can protect neurons from diverse cellular insults, including alpha-synuclein toxicity, proteasomal dysfunction, Pael-R accumulation, and kainate-induced excitotoxicity. These findings suggest a central role for parkin in maintaining dopaminergic neuronal integrity and strengthen the link between AR-JP and the more common sporadic form of Parkinson's disease.

引用

页码：13 / 16

页数：4

共 22 条

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