Clinical strategies for expansion of haematopoietic stem cells

被引：106

作者：

Sorrentino, BP ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Hematol Oncol, Div Expt Hematol, Memphis, TN 38120 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2004年 / 4卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri1487

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Haematopoietic stem cells (HSCs) give rise to all blood and immune cells and are used in clinical transplantation protocols to treat a wide variety of diseases. The ability to increase the number of HSCs either in vivo or in vitro would provide new treatment options, but the amplification of HSCs has been difficult to achieve. Recent insights into the mechanisms of HSC self-renewal now make the amplification of HSCs a plausible clinical goal. This article reviews the molecular mechanisms that control HSC numbers and discusses how these can be modulated to increase the number of HSCs. Clinical applications of HSC expansion are then discussed for their potential to address the current limitations of HSC transplantation.

引用

页码：878 / 888

页数：11

共 97 条

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