Combined Adaptiveness of Specific Motor Cortical Ensembles Underlies Learning

被引:27
作者
Arce, Fritzie [1 ,5 ]
Novick, Itai [5 ]
Mandelblat-Cerf, Yael [5 ]
Israel, Zvi [3 ]
Ghez, Claude [2 ]
Vaadia, Eilon [4 ,5 ]
机构
[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Physiol, IL-91120 Jerusalem, Israel
[2] Columbia Univ, Coll Phys & Surg, Ctr Neurobiol & Behav, New York, NY 10032 USA
[3] Hadassah Univ Hosp, Dept Neurosurg, IL-91120 Jerusalem, Israel
[4] Hadassah Univ Hosp, Interdisciplinary Ctr Neural Computat, IL-91120 Jerusalem, Israel
[5] Hadassah Univ Hosp, Hadassah Med Sch, Inst Med Res Israel Canada, Dept Med Neurobiol, IL-91120 Jerusalem, Israel
关键词
FREE ARM MOVEMENTS; REACHING MOVEMENTS; CELL DISCHARGE; 3-DIMENSIONAL SPACE; VISUAL TARGETS; CORTEX; DIRECTION; REPRESENTATION; MECHANISMS; DYNAMICS;
D O I
10.1523/JNEUROSCI.0076-10.2010
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Learning motor skills entails adaptation of neural computations that can generate or modify associations between sensations and actions. Indeed, humans can use different strategies when adapting to dynamic loads depending on available sensory feedback. Here, we examined how neural activity in motor cortex was modified when monkeys made arm reaches to a visual target and locally adapted to curl force field with or without visual trajectory feedback. We found that firing rates of a large subpopulation of cells were consistently modulated depending on the distance of their preferred direction from the learned movement direction. The newly acquired activity followed a cosine-like function, with maximal increase in directions that opposed the perturbing force and decrease in opposite directions. As a result, the combined neuronal activity generated an adapted population vector. The results suggest that this could be achieved without changing the tuning properties of the cells. This population directional signal was however altered in the absence of visual feedback; while the cosine pattern of modulation was maintained, the population distributions of modulated cells differed across feedback consistent with the different trajectory shapes. Finally, we predicted generalization patterns of force-field learning based on the cosine-like modulation. These conformed to reported features of generalization in humans, suggesting that the generalization function was related to the observed rate modulations in the motor cortex. Overall, the findings suggest that the new combined activation of neuronal ensembles could underlie the change in the internal model of movement dynamics in a way that depends on available sensory feedback and chosen strategy.
引用
收藏
页码:5415 / 5425
页数:11
相关论文
共 63 条
  • [41] Preparatory activity in motor cortex reflects learning of local visuomotor skills
    Paz, R
    Boraud, T
    Natan, C
    Bergman, H
    Vaadia, E
    [J]. NATURE NEUROSCIENCE, 2003, 6 (08) : 882 - 890
  • [42] Generalization in vision and motor control
    Poggio, T
    Bizzi, E
    [J]. NATURE, 2004, 431 (7010) : 768 - 774
  • [43] POGGIO T, 1990, COLD SPRING HARB SYM, V55, P899
  • [44] Information processing with population codes
    Pouget, A
    Dayan, P
    Zemel, R
    [J]. NATURE REVIEWS NEUROSCIENCE, 2000, 1 (02) : 125 - 132
  • [45] Computational approaches to sensorimotor transformations
    Pouget, Alexandre
    Snyder, Lawrence H.
    [J]. NATURE NEUROSCIENCE, 2000, 3 (11) : 1192 - 1198
  • [46] On the relationship between joint angular velocity and motor cortical discharge during reaching
    Reina, GA
    Moran, DW
    Schwartz, AB
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 2001, 85 (06) : 2576 - 2589
  • [47] Neocortical mechanisms in motor learning
    Sanes, JN
    [J]. CURRENT OPINION IN NEUROBIOLOGY, 2003, 13 (02) : 225 - 231
  • [48] Separate adaptive mechanisms for controlling trajectory and final position in reaching
    Scheidt, Robert A.
    Ghez, Claude
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 2007, 98 (06) : 3600 - 3613
  • [49] SCHWARTZ AB, 1988, J NEUROSCI, V8, P2913
  • [50] Differential representation of perception and action in the frontal cortex
    Schwartz, AB
    Moran, DW
    Reina, GA
    [J]. SCIENCE, 2004, 303 (5656) : 380 - 383