Vitamin D insufficiency: implications for the immune system

被引：80

作者：

Baeke, Femke ^{[1
]}

Gysemans, Conny ^{[1
]}

Korf, Hannelie ^{[1
]}

Mathieu, Chantal ^{[1
]}

机构：

[1] Katholieke Univ Leuven, LEGENDO, Lab Expt Med & Endocrinol, B-3000 Louvain, Belgium

来源：

PEDIATRIC NEPHROLOGY | 2010年 / 25卷 / 09期

关键词：

Vitamin D; Immune modulation; Chronic kidney disease; REGULATORY T-CELLS; CHRONIC KIDNEY-DISEASE; NITRIC-OXIDE SYNTHASE; 1,25-DIHYDROXYVITAMIN D-3; D DEFICIENCY; DENDRITIC CELLS; D-RECEPTOR; 25-HYDROXYVITAMIN D-1-ALPHA-HYDROXYLASE; MYCOBACTERIUM-TUBERCULOSIS; MESSENGER-RNA;

D O I：

10.1007/s00467-010-1452-y

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Chronic kidney disease (CKD) is characterized by a loss of kidney function and dysregulation of vitamin D metabolism. Well known are the defects in final activation of vitamin D to 1,25-dihydroxyvitamin D-3 [1,25(OH)(2)D-3], resulting in renal osteodystrophy. However, in recent years, 1,25(OH)(2)D-3 has been identified as having effects far beyond calcium and bone metabolism. In this review, specific attention is given to the effects of 1,25(OH)(2)D-3 on the immune system and the implications of vitamin D deficiency, a feature of many patients with CKD, on immune function.

引用

页码：1597 / 1606

页数：10

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