Role of the JAK/STAT signal transduction pathway in the regulation of gene expression in CNS

被引：31

作者：

Dell'Albani, P

Santangelo, R

Torrisi, L

Nicoletti, VG

Stella, AMG

机构：

[1] CNR, Inst Neurol Sci, I-95123 Catania, Italy

[2] Univ Catania, Dept Chem Sci, Biochem & Mol Biol Sect, I-95125 Catania, Italy

来源：

NEUROCHEMICAL RESEARCH | 2003年 / 28卷 / 01期

关键词：

JAKs; STATs; signal transduction; CNS; gene expression;

D O I：

10.1023/A:1021644027850

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Over the last 20 years the JAK/STAT signal transduction pathway has been extensively studied. An enormous amount of data on different cell signal transduction pathways is now available. The JAK/STAT signal transduction pathway is one of the intracellular signaling pathways activated by cytokines and growth factors that was first studied in the hematopoietic system, but recent data demonstrate that this signal transduction is also greatly utilized by other systems. The JAK/STAT pathway is a signaling cascade that links the activation of specific cell membrane receptors to nuclear gene expression. This review is focused on the role of JAK/STAT signal transduction pathway activation in the central nervous system (CNS).

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页码：53 / 64

页数：12

相关论文

共 94 条

[51] Structure and function of a new STAT-induced STAT inhibitor [J].

Naka, T ;

Narazaki, M ;

Hirata, M ;

Matsumoto, T ;

Minamoto, S ;

Aono, A ;

Nishimoto, N ;

Kajita, T ;

Taga, T ;

Yoshizaki, K ;

Akira, S ;

Kishimoto, T .

NATURE, 1997, 387 (6636) :924-929

[52] Cellular physiology of STAT3: Where's the cytoplasmic monomer? [J].

Ndubuisi, MI ;

Guo, GG ;

Fried, VA ;

Etlinger, JD ;

Sehgal, PB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (36) :25499-25509

[53] Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis [J].

Neubauer, H ;

Cumano, A ;

Muller, M ;

Wu, H ;

Huffstadt, U ;

Pfeffer, K .

CELL, 1998, 93 (03) :397-409

[54] Effect of nitric oxide synthase induction on the expression of mitochondrial respiratory chain enzyme subunits in mixed cortical and astroglial cell cultures [J].

Nicoletti, VG ;

Caruso, A ;

Tendi, EA ;

Privitera, A ;

Console, A ;

Calabrese, V ;

Spadaro, F ;

Ravagna, A ;

Copani, A ;

Stella, AMG .

BIOCHIMIE, 1998, 80 (10) :871-881

[55] Jak2 is essential for signaling through a variety of cytokine receptors [J].

Parganas, E ;

Wang, D ;

Stravopodis, D ;

Topham, DJ ;

Marine, JC ;

Teglund, S ;

Vanin, EF ;

Bodner, S ;

Colamonici, OR ;

van Deursen, JM ;

Grosveld, G ;

Ihle, JN .

CELL, 1998, 93 (03) :385-395

[56] Immune response in stat2 knockout mice [J].

Park, C ;

Li, S ;

Cha, E ;

Schindler, C .

IMMUNITY, 2000, 13 (06) :795-804

[57] 2 SIGNALS MEDIATE HORMONE-DEPENDENT NUCLEAR-LOCALIZATION OF THE GLUCOCORTICOID RECEPTOR [J].

PICARD, D ;

YAMAMOTO, KR .

EMBO JOURNAL, 1987, 6 (11) :3333-3340

[58] Induction of Stat3, a signal transducer and transcription factor, in reactive microglia following transient focal cerebral ischaemia [J].

Planas, AM ;

Soriano, MA ;

Berruezo, M ;

Justicia, C ;

Estrada, A ;

Pitarch, S ;

Ferrer, I .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1996, 8 (12) :2612-2618

[59] JAK2 ASSOCIATES WITH THE BETA(C) CHAIN OF THE RECEPTOR FAR GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR, AND ITS ACTIVATION REQUIRES THE MEMBRANE-PROXIMAL REGION [J].

QUELLE, FW ;

SATO, N ;

WITTHUHN, BS ;

INHORN, RC ;

EDER, M ;

MIYAJIMA, A ;

GRIFFIN, JD ;

IHLE, JN .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (07) :4335-4341

[60]

Rayanade RJ, 1998, J IMMUNOL, V161, P325

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