Activity of iPMS and nPMS in mouse bone marrow micronucleus assays: Comparison with mouse dominant lethal assay data

被引：5

作者：

Adler, ID

Tinwell, H

Kliesch, U

Ashby, J

机构：

[1] ZENECA CENT TOXICOL LAB,MACCLESFIELD SK10 4TJ,CHESHIRE,ENGLAND

[2] GSF,INST SAUGETIERGENET,D-85758 OBERSCHLEISSHEIM,GERMANY

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1996年 / 349卷 / 02期

关键词：

bone marrow; isopropyl methanesulfonate; n-propyl methanesylfonate;

D O I：

10.1016/0027-5107(95)00188-3

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

isoPropyl methanesulphonate (iPMS) and its n-propyl analogue (nPMS) are shown to be active in mouse bone marrow micronucleus assays using male CBA, male and female (C3H/El X 102/El)F1 and male and female Muta(TM)Mouse mice. iPMS was significantly more active than nPMS. No significant strain or gender differences were observed. These findings reflect the differences reported earlier for these two chemicals in mouse dominant lethal mutation assays. The earlier described dominant lethal assay data are represented schematically and discussed.

引用

页码：241 / 247

页数：7

共 15 条

[1]

Adler I.-D., 1984, MUTAGENICITY TESTING, P275

[2] THE PRESENT LACK OF EVIDENCE FOR UNIQUE RODENT GERM-CELL MUTAGENS [J].