New oligonucleotide analogues based on morpholine subunits joined by oxalyl diamide tether

被引：14

作者：

Abramova, Tatiana V.

Kassakin, Marat F.

Lomzov, Alexander A.

Pyshnyi, Dmitrii V.

Silnikov, Vladimir N.

机构：

[1] Inst Chem Biol & Fundamental Med, Novosibirsk 630090, Russia

[2] Novosibirsk State Univ, Novosibirsk 630090, Russia

来源：

BIOORGANIC CHEMISTRY | 2007年 / 35卷 / 03期

关键词：

oligonucleotide analogues; morpholine nucleosides; aminonucleosides;

D O I：

10.1016/j.bioorg.2006.12.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report on the design, synthesis and some of the properties of the new oligonucleotide analogues based on morpholine nucleoside (MorB) subunits joined by an oxalyl diamide tether instead of a phosphate group. The synthetic strategy and oligomer design are optimized to easily obtain target substances without using protective groups. The dimers HOMorU-Ox-NHMorU, HOMorU-Ox-NHMorA, and uracil containing the hexamer HOMorU-(Ox-NHMorU)(5) were synthesized. The structures of all substances were confirmed by H-1, C-13, NMR, and mass spectroscopy. Base stacking interactions in dimers were revealed by CD-spectra data. (C) 2007 Elsevier Inc. All rights reserved.

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页码：258 / 275

页数：18

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