The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation

被引：303

作者：

Beavon, IRG ^{[1
]}

机构：

[1] S African Inst Med Res, Sch Pathol, Dept Anat Pathol, Johannesburg, South Africa

[2] Univ Witwatersrand, Johannesburg, South Africa

来源：

EUROPEAN JOURNAL OF CANCER | 2000年 / 36卷 / 13期

关键词：

E-cadherin; catenins; cell adhesion; cell signalling; regulation; tumour metastasis; hypoxia; growth factors; epidermal growth factor receptor;

D O I：

10.1016/S0959-8049(00)00158-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

E-cadherin and the associated catenin complex have been recognised as performing a key role in cell adhesion. Loss of cell adhesion is seen as a key step in the cascade leading to tumour metastasis. The ability of both extra- and intracellular factors to regulate E-cadherin-mediated cell adhesion in physiological processes has provided insight into both the interactions of the E-cadherin-catenin complex, and possible mechanisms utilised by tumours in the process of metastasis. The interaction of thr E-cadherin-catenin complex with various regulating factors, their effect on cell signalling pathways, and the relationship with the metastatic potential of tumours are reviewed. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1607 / 1620

页数：14

共 213 条

[51] E-CADHERIN EXPRESSION IN INTESTINAL EPITHELIUM
DOGAN, A
WANG, ZD
SPENCER, J
[J]. JOURNAL OF CLINICAL PATHOLOGY, 1995, 48 (02) : 143 - 146
[52] Dorkin TJ, 1997, J PATHOL, V183, P380, DOI 10.1002/(SICI)1096-9896(199712)183:4<380::AID-PATH959>3.0.CO
[53] 2-7
[54] DORUDI S, 1993, AM J PATHOL, V142, P981
[55] THE UROKINASE RECEPTOR - INVOLVEMENT IN CELL-SURFACE PROTEOLYSIS AND CANCER INVASION
ELLIS, V
PYKE, C
ERIKSEN, J
SOLBERG, H
DANO, K
[J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1992, 667 : 13 - 31
[56] ANGIOGENESIS IN CANCER, VASCULAR, RHEUMATOID AND OTHER DISEASE
FOLKMAN, J
[J]. NATURE MEDICINE, 1995, 1 (01) : 27 - 31
[57] Cdc42 and Rac1 regulate the interaction of IQGAP1 with β-catenin
Fukata, M
Kuroda, S
Nakagawa, M
Kawajiri, A
Itoh, N
Shoji, I
Matsuura, Y
Yonehara, S
Fujisawa, H
Kikuchi, A
Kaibuchi, K
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (37) : 26044 - 26050
[58] Evolution of the "classical" cadherin family of cell adhesion molecules in vertebrates
Gallin, WJ
[J]. MOLECULAR BIOLOGY AND EVOLUTION, 1998, 15 (09) : 1099 - 1107
[59] GAMALLO C, 1993, AM J PATHOL, V142, P987
[60] Garner AP, 1999, CANCER RES, V59, P1929

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