Inositol tripyrophosphate: a new membrane permeant allosteric effector of haemoglobin

被引：45

作者：

Fylaktakidou, KC

Lehn, JM

Greferath, R

Nicolau, C

机构：

[1] Univ Strasbourg 1, ISIS, Lab Chim Supramol, F-67083 Strasbourg, France

[2] Hop Univ, IRCAD EITS, F-67091 Strasbourg, France

[3] Ecole Polytech Fed Lausanne, PSEB, AC Immune SA, CH-1015 Lausanne, Switzerland

[4] Tufts Univ, Friedman Ctr Nutr Sci & Policy, Boston, MA 02115 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 06期

关键词：

inositol tripyrophosphate; haemoglobin; red blood cells; myo-Inositol hexakis phosphate;

D O I：

10.1016/j.bmcl.2005.01.064

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nine inositol tripyrophosphate (ITPP) salts have been synthesized. Their ability to act as allosteric effectors of haemoglobin (Hb) has been measured in vitro with free Hb and whole blood. All the synthesized compounds bound to free Hb and were also able to cross, to a certain extent, the plasma membrane of the red blood cells (RBCs) in whole blood samples, lowering the affinity of Hb for oxygen. The oxy-haemoglobin dissociation curves were significantly shifted towards higher values of oxygen partial pressures, both for free Hb and for intracellular Hb in whole blood. (c) 2005 Elsevier Ltd. All rights reserved.

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页码：1605 / 1608

页数：4

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