Organic-catalyst-mediated cyclopropanation reaction

被引：162

作者：

Papageorgiou, CD ^{[1
]}

Ley, SV ^{[1
]}

Gaunt, MJ ^{[1
]}

机构：

[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 07期

关键词：

asymmetric synthesis; cyclopropanation; diastereoselectivity; organocatalysis; ylides;

D O I：

10.1002/anie.200390222

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A catalytic ammonium ylide based cyclopropanation process forms trans-disubstituted cyclopropanes in good yield upon reaction with electron-deficient alkenes (see scheme; EWG = electron-withdrawing group). The reaction is also highly enantioselective when a stoichiometric amount of a chiral tertiary amine is used.

引用

页码：828 / 831

页数：4

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