Endoplasmic reticulum, Bcl-2 and Ca2+ handling in apoptosis

被引:79
作者
Ferrari, D
Pinton, P
Szabadkai, G
Chami, M
Campanella, M
Pozzan, T
Rizzuto, R
机构
[1] Univ Ferrara, Dept Expt & Diagnost Med, Sect Gen Pathol, TCI, I-44100 Ferrara, Italy
[2] Univ Ferrara, ICSI, I-44100 Ferrara, Italy
[3] Univ Padua, Dept Biomed Sci, I-35121 Padua, Italy
[4] Univ Padua, CNR, Ctr Study Biomembranes, I-35121 Padua, Italy
关键词
D O I
10.1016/S0143416002002014
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In the complex signalling interplay that allows extracellular signals to be decoded into activation of apoptotic cell death, Ca2+ plays a significant role. This is supported not only by evidence linking alterations in Ca2+ homeostasis to the triggering of apoptotic (and in some cases necrotic) cell death, but also by recent data indicating that a key anti-apoptotic protein, Bcl-2, has a direct effect on ER Ca2+ handling. We-will briefly summarise the first aspect, and describe in more detail these new data, demonstrating that (i) Bcl-2 reduces the state of filling of the ER Ca2+ store and (ii) this Ca2+ signalling alteration renders the cells less sensitive to apoptotic stimuli. Overall, these results suggest that calcium homeostasis may represent a pharmacological target in the fundamental pathological process of apoptosis. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:413 / 420
页数:8
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