Genetic and environmental factors interact to influence anxiety

被引:37
作者
Gross, C
Hen, R [1 ]
机构
[1] Columbia Univ, Ctr Neurobiol & Behav, New York, NY 10032 USA
[2] EMBL, I-00016 Monterotondo, Italy
关键词
anxiety; depression; plasticity; neurogenesis; post traumatic stress disorder (PTSD); 5-HT1A receptor; serotonin; transgenic; knockout;
D O I
10.1007/BF03033286
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Both genetic and environmental factors influence normal anxiety traits as well as anxiety disorders. In addition it is becoming increasingly clear that these factors interact to produce specific anxiety-related behaviors. For example, in humans and in monkeys mutations in the gene encoding for the serotonin transporter result in increased anxiety in adults life when combined with a stressful environment during development. Another recent example comes from twin studies suggesting that a small hippocampus can be a predisposing condition that renders individuals susceptible to post traumatic stress disorder. Such examples illustrate how specific mutations leading to abnormal brain development may increase vulnerability to environmental insults which may in turn lead to specific anxiety disorders.
引用
收藏
页码:493 / 501
页数:9
相关论文
共 90 条
[31]   Serotonin transporter genetic variation and the response of the human amygdala [J].
Hariri, AR ;
Mattay, VS ;
Tessitore, A ;
Kolachana, B ;
Fera, F ;
Goldman, D ;
Egan, MF ;
Weinberger, DR .
SCIENCE, 2002, 297 (5580) :400-403
[32]   TOTAL SOCIAL ISOLATION IN MONKEYS [J].
HARLOW, HF ;
DODSWORTH, RO ;
HARLOW, MK .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1965, 54 (01) :90-+
[33]   TREATMENT OF OBSESSIVE-COMPULSIVE DISORDER BY PSYCHOSURGERY [J].
HAY, P ;
SACHDEV, P ;
CUMMING, S ;
SMITH, JS ;
LEE, T ;
KITCHENER, P ;
MATHESON, J .
ACTA PSYCHIATRICA SCANDINAVICA, 1993, 87 (03) :197-207
[34]   Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice [J].
Heisler, LK ;
Chu, HM ;
Brennan, TJ ;
Danao, JA ;
Bajwa, P ;
Parsons, LH ;
Tecott, LH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) :15049-15054
[35]   A review and meta-analysis of the genetic epidemiology of anxiety disorders [J].
Hettema, JM ;
Neale, MC ;
Kendler, KS .
AMERICAN JOURNAL OF PSYCHIATRY, 2001, 158 (10) :1568-1578
[36]   Targeted gene mutation approaches to the study of anxiety-like behavior in mice [J].
Holmes, A .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2001, 25 (03) :261-273
[37]   Early childhood predictors of adult anxiety disorders [J].
Kagan, J ;
Snidman, N .
BIOLOGICAL PSYCHIATRY, 1999, 46 (11) :1536-1541
[38]   Long-lasting changes in stress-induced corticosterone response and anxiety-like behaviors as a consequence of neonatal maternal separation in Long-Evans rats [J].
Kalinichev, M ;
Easterling, KW ;
Plotsky, PM ;
Holtzman, SG .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2002, 73 (01) :131-140
[39]   Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase [J].
Kash, SF ;
Tecott, LH ;
Hodge, C ;
Baekkeskov, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (04) :1698-1703
[40]  
Kaufman J, 2000, DEPRESS ANXIETY, V12, P69, DOI 10.1002/1520-6394(2000)12:1+<69::AID-DA9>3.0.CO