Childhood maltreatment predicts adult inflammation in a life-course study

被引:858
作者
Danese, Andrea
Pariante, Carmine M.
Caspi, Avshalom
Taylor, Alan
Poulton, Richie
机构
[1] Kings Coll London, MRC, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England
[2] Kings Coll London, Inst Psychiat, Dept Med Psychol, London SE5 8AF, England
[3] Duke Univ, Dept Psychol & Neurosci, Durham, NC 27708 USA
[4] Duke Univ, Dept Psychiat, Durham, NC 27708 USA
[5] Duke Univ, Dept Behav Sci, Durham, NC 27708 USA
[6] Duke Univ, Inst Genome Sci & Policy, Durham, NC 27708 USA
[7] Univ Otago, Dunedin Sch Med, Dunedin 9015, New Zealand
基金
英国医学研究理事会;
关键词
C-reactive protein; development; epidemiology; risk factor; stress;
D O I
10.1073/pnas.0610362104
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Stress in early life has been associated with insufficient glucocorticoid signaling in adulthood, possibly affecting inflammation processes. Childhood maltreatment has been linked to increased risk of adult disease with potential inflammatory origin. However, the impact of early life stress on adult inflammation is not known in humans. We tested the life-course association between childhood maltreatment and adult inflammation in a birth cohort followed to age 32 years as part of the Dunedin Multidisciplinary Health and Development Study. Regression models were used to estimate the effect of maltreatment on inflammation, adjusting for co-occurring risk factors and potential mediating variables. Maltreated children showed a significant and graded increase in the risk for clinically relevant C-reactive protein levels 20 years later, in adulthood [risk ratio (RR) = 1.80, 95% confidence interval (CI) = 1.26-2.58]. The effect of childhood maltreatment on adult inflammation was independent of the influence of co-occurring early life risks (RR = 1.58, 95% CI = 1.08-2.31), stress in adulthood (RR = 1.64, 95% CI = 1.12-2.39), and adult health and health behavior (RR = 1.76, 95% CI = 1.23-2.51). More than 10% of cases of low-grade inflammation in the population, as indexed by high C-reactive protein, may be attributable to childhood maltreatment. The association between maltreatment and adult inflammation also generalizes to fibrinogen and white blood cell count. Childhood maltreatment is a previously undescribed, independent, and preventable risk factor for inflammation in adulthood. Inflammation may be an important developmental mediator linking adverse experiences in early life to poor adult health.
引用
收藏
页码:1319 / 1324
页数:6
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