What we do and don't know about 'race', 'ethnicity', genetics and health at the dawn of the genome era

被引:196
作者
Collins, FS [1 ]
机构
[1] NHGRI, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1038/ng1436
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
A true understanding of disease risk requires a thorough examination of root causes. 'Race' and 'ethnicity' are poorly defined terms that serve as flawed surrogates for multiple environmental and genetic factors in disease causation, including ancestral geographic origins, socioeconomic status, education and access to health care. Research must move beyond these weak and imperfect proxy relationships to define the more proximate factors that influence health.
引用
收藏
页码:S13 / S15
页数:3
相关论文
共 11 条
[1]  
[Anonymous], 2000, NEW YORK TIMES
[2]   Deconstructing the relationship between genetics and race [J].
Bamshad, M ;
Wooding, S ;
Salisbury, BA ;
Stephens, JC .
NATURE REVIEWS GENETICS, 2004, 5 (08) :598-U2
[3]   The importance of race and ethnic background in biomedical research and clinical practice [J].
Burchard, EG ;
Ziv, E ;
Coyle, N ;
Gomez, SL ;
Tang, H ;
Karter, AJ ;
Mountain, JL ;
Pérez-Stable, EJ ;
Sheppard, D ;
Risch, N .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (12) :1170-1175
[4]   A vision for the future of genomics research [J].
Collins, FS ;
Green, ED ;
Guttmacher, AE ;
Guyer, MS .
NATURE, 2003, 422 (6934) :835-847
[5]   The case for a US prospective cohort study of genes and environment [J].
Collins, FS .
NATURE, 2004, 429 (6990) :475-477
[6]   Race and genomics [J].
Cooper, RS ;
Kaufman, JS ;
Ward, R .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (12) :1166-1170
[7]   The International HapMap Project [J].
Gibbs, RA ;
Belmont, JW ;
Hardenbol, P ;
Willis, TD ;
Yu, FL ;
Yang, HM ;
Ch'ang, LY ;
Huang, W ;
Liu, B ;
Shen, Y ;
Tam, PKH ;
Tsui, LC ;
Waye, MMY ;
Wong, JTF ;
Zeng, CQ ;
Zhang, QR ;
Chee, MS ;
Galver, LM ;
Kruglyak, S ;
Murray, SS ;
Oliphant, AR ;
Montpetit, A ;
Hudson, TJ ;
Chagnon, F ;
Ferretti, V ;
Leboeuf, M ;
Phillips, MS ;
Verner, A ;
Kwok, PY ;
Duan, SH ;
Lind, DL ;
Miller, RD ;
Rice, JP ;
Saccone, NL ;
Taillon-Miller, P ;
Xiao, M ;
Nakamura, Y ;
Sekine, A ;
Sorimachi, K ;
Tanaka, T ;
Tanaka, Y ;
Tsunoda, T ;
Yoshino, E ;
Bentley, DR ;
Deloukas, P ;
Hunt, S ;
Powell, D ;
Altshuler, D ;
Gabriel, SB ;
Qiu, RZ .
NATURE, 2003, 426 (6968) :789-796
[8]   Lack of common NOD2 variants in Japanese patients with Crohn's disease [J].
Inoue, N ;
Tamura, K ;
Kinouchi, Y ;
Fukuda, Y ;
Takahashi, S ;
Ogura, Y ;
Inohara, N ;
Núñez, G ;
Kishi, Y ;
Koike, Y ;
Shimosegawa, T ;
Shimoyama, T ;
Hibi, T .
GASTROENTEROLOGY, 2002, 123 (01) :86-91
[9]   DNA studies challenge the meaning of race [J].
Marshall, E .
SCIENCE, 1998, 282 (5389) :654-655
[10]   Genetic structure of human populations [J].
Rosenberg, NA ;
Pritchard, JK ;
Weber, JL ;
Cann, HM ;
Kidd, KK ;
Zhivotovsky, LA ;
Feldman, MW .
SCIENCE, 2002, 298 (5602) :2381-2385