A two-step method for the preparation of homochiral cathinones

被引：23

作者：

Osorio-Olivares, M

Rezende, MC

Sepúlveda-Boza, S

Cassels, BK

Baggio, RF

Muñoz-Acevedo, JC

机构：

[1] Univ Santiago Chile, Fac Quim & Biol, Santiago, Chile

[2] Univ Santiago Chile, Fac Ciencias Med, Santiago, Chile

[3] Univ Chile, Fac Ciencias, Dept Quim, Santiago, Chile

[4] Univ Chile, Fac Ciencias, Millennium Inst Adv Studies Cell Biol & Biotechno, Santiago, Chile

[5] Comis Nacl Energia Atom, Dept Fis, RA-1429 Buenos Aires, DF, Argentina

[6] Univ Chile, Fac Ciencias Fis & Matemat, Santiago, Chile

来源：

TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 11期

关键词：

D O I：

10.1016/S0957-4166(03)00317-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A simple method for the preparation of homochiral ring-substituted 1-aryl-2-aminopropanones 2 ('cathinones') is described, involving initial Friedel-Crafts acylation of aromatics with (S)- or (R)-N-trifluoroacetylalanyl chloride, followed by acid hydrolysis of the intermediate trifluoroacetamido intermediates 1. for which X-ray diffraction analysis confirmed the structures. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1473 / 1477

页数：5

共 18 条

[11] Effects of 5-HT-releasing agents on the extracellullar hippocampal 5-HT of rats. Implications for the development of novel antidepressants with a short onset of action [J].