Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation

被引：614

作者：

Matsuoka, Masao

Jeang, Kuan-Teh

机构：

[1] NIAID, Lab Mol Microbiol, NIH, Bethesda, MD 20892 USA

[2] Kyoto Univ, Lab Virus Immunol, Inst Virus Res, Kyoto, Japan

来源：

NATURE REVIEWS CANCER | 2007年 / 7卷 / 04期

关键词：

D O I：

10.1038/nrc2111

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

It has been 30 years since a 'new' leukaemia termed adult T-cell leukaemia (ATL) was described in Japan, and more than 25 years since the isolation of the retrovirus, human T-cell leukaemia virus type 1 (HTLV-1), that causes this disease. We discuss HTLV-1 infectivity and how the HTLV-1 Tax oncoprotein initiates transformation by creating a cellular environment favouring aneuploidy and clastogenic DNA damage. We also explore the contribution of a newly discovered protein and RNA on the HTLV-1 minus strand, HTLV-1 basic leucine zipper factor (HBZ), to the maintenance of virus-induced leukaemia.

引用

收藏

页码：270 / 280

页数：11

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